Kaohsiung Medical University

Academia Sinica

Chien-Han Kao

Tian-Lu Cheng

Kuo-Hsiang Chuang

Yu-Cheng Su

Steven R Roffler

Bing-Mae Chen

Hsin-Yi Tung

Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Bi-specific antibodies and uses thereof

Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Growing community of inventors

Kaohsiung, Taiwan

Chien-Han Kao