Tsinghua University

Mackay Memorial Hospital

Chien-Chong Hong

Tong-Miin Liou

Wen Chung

Shih-Hong You

Chung-Hsuan Wu

Chih-Chung Lin

Kai-Lun Lin

Szu-Ying Chen

Kuan-Wen Chen

Yan-Ren Chen

Shih-Pang Wang

Chie-Pein Chen

Kuo-Chu Hwang

Alan Chen

Tong-Min Liou

Guan-Lin Chen

Guo-Shin Lu

Zi-Xiang Lin

Jia-Cherng Horng

Jheng-Ying Wu

Chia-Hung Lee

Meng-Hua Chung

Po-Hsiang Chang

Cheng-Han Tsai

Sheng-Yuan Huang

Wei-Han Wang

Jui-Chun Chen

A biosensor for detecting the presence of a target compound in a test solution is disclosed. The biosensor includes upper and lower carrier plates, a spacer film with a micro-channel, an inlet port upstream of the micro-channel, an outlet port downstream of the micro-channel, a micro-machined transceiver, and a first molecularly imprinted polymer layer for recognizing and binding the target compound. The micro-machined transceiver includes a micro-machined transmitter for generating an acoustic wave, and micro-machined receiver for generating an acoustic wave-induced voltage. An amplitude of the acoustic wave-induced voltage is varied in response to the concentration of the target compound.

Biosensor

A method for fabricating microfluidic structures is provided. The method includes: a belt is provided and an adhesion layer is formed on at least one surface of the belt; the belt is cut for forming a first microfluidic channel thereon, wherein the first microfluidic channel has an accommodating space; a second microfluidic channel is provided, wherein a line-width of the second microfluidic channel is smaller than a line-width of the first microfluidic channel; the second microfluidic channel is disposed in the accommodating space of the first microfluidic channel; and a substrate is adhered to the belt via the adhesion layer.

Method for fabricating microfluidic structures

The present invention proposes an electrode thin film and a method for manufacturing the electrode thin film. The method includes: determining a height between a first roller and a substrate and a coating speed for the first roller coating a first metal nanowire suspension liquid onto the substrate based on a suspension property of the first metal nanowire suspension liquid; coating, by using the first roller, the first metal nanowire suspension liquid onto the substrate with the coating speed to form a wetting film on the substrate; and controlling a first temperature of the substrate heating the wetting film based on the suspension property of the first metal nanowire suspension liquid to dry the wetting film as the electrode thin film. The first temperature makes a dewetting speed of the wetting film higher than a drying speed of the wetting film.

Electrode thin film and method for manufacturing the same

A method for promoting an electric output of a piezoelectric/conductive hybrid polymer is provided. The method includes forming a piezoelectric/conductive hybrid polymer by mixing poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) so as to increase an output current and an output power of the piezoelectric/conductive hybrid polymer; and changing a surface structure of the piezoelectric/conductive hybrid polymer by a nano-imprint process for promoting a piezoelectricity of the piezoelectric/conductive hybrid polymer. As a result, an output voltage, the output current and the output power of the piezoelectric/conductive hybrid polymer are increased.

Method of promoting electric output of piezoelectric/conductive hybrid polymer

A method for determining a threshold voltage for a batch of sensing chips includes steps of: a) selecting at least three of micro-machined transceivers; b) conducting for each of the at least three of the micro-machined transceivers the following sub-steps of: b1) introducing a blank liquid into a micro-channel via an inlet port, b2) applying an alternate voltage to a micro-machined transmitter for a period of time, and b3) measuring an amplitude of an electric signal from a micro-machined receiver to obtain a maximum value and a minimum value; c) measuring a mid-value; and d) determining the threshold voltage. Also disclosed is a method for increasing sensitivity of the batch of sensing chips based on the threshold voltage.

Method for determining a threshold voltage for obtaining a batch of sensing chips with increased sensitivity and method for increasing sensitivity of the batch of sensing chips

Microfluidic structures fabricating method

A microfluidic device includes a substrate, first and second capillary inlets, a microfluidic channel unit, an outlet disposed downstream of the microfluidic channel unit, and a suction member disposed downstream of the outlet. A first liquid is drawn into a first sub-channel and a main channel of the microfluidic channel unit through the first capillary inlet. A second liquid is drawn into a second sub-channel of the microfluidic channel unit through the second capillary inlet. The suction member provides a predetermined suction force to permit the second liquid to penetrate into the first liquid and to break up into droplets in the first liquid, thereby generating monodisperse emulsions.

Microfluidic device

A method of fabricating a piezoelectric/conductive hybrid polymer thin film is provided, which is promoting an electric output of a piezoelectric polymer and includes: a mixing step including: forming a piezoelectric solution by dissolving a PVDF-TrFE in an active solvent; forming a conductive solution by dissolving a PEDOT:PSS in a water; and forming a piezoelectric/conductive hybrid polymer solution by mixing the piezoelectric solution and the conductive solution; a filming step, wherein the piezoelectric/conductive hybrid polymer solution is heated, thus the piezoelectric/conductive hybrid polymer thin film is formed; and an anneal step, wherein the piezoelectric/conductive hybrid polymer thin film is recrystallized and a nano-sized protruding structure is formed on a surface of the piezoelectric/conductive hybrid polymer thin film.

Method of promoting electric output of piezoelectric/conductive hybrid polymer and fabricating method of piezoelectric/conductive hybrid polymer thin film

A molybdenum disulfide sensor includes a flexible substrate, a patterned circuit layer and at least a molybdenum disulfide sheet. The flexible substrate has a gas flow channel. The patterned circuit layer is formed on the flexible substrate, and the patterned circuit layer includes a first electrode and a second electrode. The second electrode is faced toward the first electrode, and a gap is formed between the first electrode and the second electrode. The molybdenum disulfide sheet is located in the gap and is connected with the first electrode and the second electrode.

Molybdenum disulfide sensor and method for fabricating the same

A method of making a breath sensing tube includes: (A) dispersing a nanowire material in a solution in a dielectriphoretic bath, such that the nanowire material is formed into individual nanowires and nanowire aggregates; (B) adsorbing the nanowire aggregates on a bath electrode through dielectrophoresis so as to obtain a nanowire-containing solution containing the individual nanowires; contacting sensor electrodes of a substrate with the nanowire-containing solution; and subjecting the nanowire-containing solution to dielectrophoresis, so that one of the individual nanowires is adsorbed to the sensor electrodes to interconnect the sensor electrodes.

Method of making a breath sensing tube

A piezoelectric device includes a nanoimprinted film which is made from a ferroelectric polymer having a first conformation state and coated on a substrate. The ferroelectric polymer is heated at a temperature between a Curie point (Tc) and a melting point (Tm) of the ferroelectric polymer to cause a change in conformation of the ferroelectric polymer from the first conformation state to a second conformation state, and is then subjected to a nanoimprinting process at an imprinting temperature lower than Tc to cause a change in conformation of the ferroelectric polymer from the second conformation state to a third conformation state that is different from the first conformation state, thereby obtaining the nanoimprinted film.

Piezoelectric device

An inkjet printing method for forming a continuous three-dimensional structure is disclosed. A pre-patterned temporary structure is formed on a substrate for defining a filling groove on the substrate. An inkjet printing process is performed for filling the ink droplets into the filling groove. The ink droplets cover the filling groove and contact the surface of the temporary structure and the substrate at the same time. A self-aligned effect is formed by a composition of the gravity of the ink droplets, a surface tension between the ink droplets and the temporary structure, and a surface tension between the ink droplets and the substrate. When the ink droplets are solidified, a standalone continuous three-dimensional structure is formed by removing the temporary structure. The geometry of the continuous three-dimensional structure can be defined by the temporary structure; therefore a small track width of the solidified ink droplets can be obtained.

Inkjet printing method for forming a continuous three-dimensional structure

The present invention provides a hybrid nanomaterial electrode, comprising a pair of spaced-apart electrodes, at least three pairs of metallic nanowires disposed between the electrodes and respectively connected with the electrodes, and at least a detecting material connecting with the metallic nanowires. The detecting material is formed as a semiconductor nanostructure or a conductor nanostructure. The hybrid nanomaterial electrode of the present invention can be used in a gas detector for detecting volatile organic compounds, and has the advantage of providing high sensitivity, low detection limit, and the ability to operate at room temperature.

Hybrid nanomaterial electrode and fabrication method thereof

The present invention is a C-reactive protein imprinted polymer film. The C-reactive protein antibody imprinted polymer film comprises a plurality of imprinted nanocavities with unified orientation and distribution formed by removing a plurality of C-reactive proteins from a polymer film. Its ability to capture the target proteins can achieve 99% compared with the natural antibodies. The present invention further provides a C-reactive protein microchip system formed by the dynamic capacitance sensing method with the above imprinted polymer film. The C-reactive protein microchip system comprises a body having a first chamber and a second chamber, and a detector.

Growing community of inventors

Zhubei, Taiwan

Chien-Chong Hong