The State University of New York

Wisconsin Alumni Research Foundation

Chien-An Chen

Scott McN Sieburth

Alfred M Mutahi

Charles J Sih

Compounds of formula (I, II, or III), wherein X is OH; Y is OH, H, lower alkyl of one to six carbons or heteroatoms or F; Z and Z' are independently H, lower alkyl or QSi where Q is lower alkyl or aryl; n is 3&#x2013;50; n&#x2032; is 2&#x2013;50; A and B are independently a) alkyl of one to ten carbons or heteroatoms, b) aryl of four to ten carbons or heteroatoms, c) cyclic of three to ten carbons or heteroatoms, or moieties of the formulas (d, e, or f); R&#x2013;Rgroups are each independently hydrogen, alkyl of one to ten carbons or heteroatoms, aryl of 4 to 14 carbons or heteroatoms, arylalkyl of five to twenty carbons or heteroatoms; unsubstituted carbonyl or substituted carbonyl. Heteroatoms are nitrogen, oxygen, silicon or sulfur. At least one of A or B, or both A and B are d), e), or f). The compounds of formula (I) inhibit protease enzymes and can be used as pharmaceuticals. 

Silanol enzyme inhibitors

Compounds of formula (I, II or III), wherein X is OH; Y is OH, H, lower alkyl of one to six carbons or heteroatoms or F; Z and Z' are independently H, lower alkyl or QSi where Q is lower alkyl or aryl; n is 3-50; n&#x2032; is 2-50; A and B are independently a) alkyl of one to ten carbons or heteroatoms, b) aryl of four to seven carbons or heteroatoms, c) cyclic of three to ten carbons or heteroatoms, or moieties of the formulas (d, e, or f); R-Rgroups are each independently hydrogen, alkyl of one to ten carbons or heteroatoms, aryl of 4 to 14 carbons or heteroatoms, arylalkyl of five to twenty carbons or heteroatoms; unsubstituted carbonyl or substituted carbonyl. Heteroatoms are nitrogen, oxygen, silicon or sulfur. At least one of A or B, or both A and B are d), e), or f). The compounds of formula (I) inhibit protease enzymes and can be used as pharmaceuticals.

Compounds of formula (I, II, or III), wherein X is OH; Y is OH, H, lower alkyl of one to six carbons or heteroatoms or F; Z and Z&prime; are independently H, lower alkyl or Q Si where Q is lower alkyl or aryl; n is 3-50; n&prime; is 2-50, A and B are independently a) alkyl of one to ten carbons or heteroatoms, b) aryl of four to ten carbons or heteroatoms, c) cyclic of three to ten carbons or heteroatoms, or moieties of the formulas (d, e, or f); R -R groups are each independently hydrogen, alkyl of one to ten carbons or heteoatoms aryl of 4 to 14 carbons or heteroatoms, arylalkyl of five to twenty carbons or heteroatoms; unsubstituted carbonyl or substituted carbonyl. Heteroatoms are nitrogen, oxygen, silicon or sulfur. At least one of A or B, or both A and B are d), e), or f). The compounds of formula (I) inhibit protease enzymes and can be used as pharmaceuticals.

The present invention provides a method of preparing conjugated polyunsaturated fatty acids wherein the fatty acid substrate has two or more double bonds and diallylic hydrogens by one or more treatments with a superstrong base. Isomeric purity can be accomplished with a further step of enzymatic hydrolysis and separation.

Growing community of inventors

Madison, WI, United States of America

Chien-An Chen