Nikon Corporation

Harvard College

Chieko Nakada

Yasujiro Kiyota

Lee L Rubin

Kumiko Matsui

Wataru Tomosugi

Keiichi Niikura

Kathleen L Pfaff

A microscope, including: an illumination optical system that irradiates a specimen with illumination light from an oblique direction; an observation optical system including an objective lens; and a controller that moves at least one of a stage to hold the specimen and the objective lens in a same direction as an optical axis of the objective lens. The controller changes, when moving at least one of the stage and the objective lens, an incident angle of the illumination light with respect to the specimen.

Microscope, observation method, and a storage medium

Provided herein are methods for analysis of target cells on a population or individual basis, including before and after contact with a stimulus in order to determine the effect of such stimulus on the target cells. Also provided are devices for performing such methods. The analysis methods involve identifying and measuring or tracking morphological changes that occur in target cells over a period of time. Tracking is accomplished using imaging systems capable of imaging target cells individually over a period of time either continuously or at discrete intervals of time.

Methods and devices for live cell imaging analysis

Growing community of inventors

Okamoto, Japan

Chieko Nakada