Mitsubishi Gas Chemical Company, Inc.

Mitbushi Gas Chemical Company, Inc.

Chieko Itoh

Teizi Urakami

Mitsunori Oda

Kazuhiro Sugamura

Toshio Nagai

Hisao Kobayashi

The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines. The thus obtained oxazopyrroloquinolines include novel compounds. The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.

Process for producing oxazopyrroloquinolines, novel

Oxazopyrroloquinolines and use of oxazopyrroloquinolines

Disclosed is a method of curing liver diseases by administration of pyrrolo quinoline quinon triesters (PQQ triesters). The PQQ triesters include PQQ triallyl ester and PQQ tribenzyl ester which are novel. The PQQ triesters being ester form, they have no toxicity and can be orally adminstered.

Method of curing liver diseases by using pyrrolo quinoline quinone

Growing community of inventors

Niigata, Japan

Chieko Itoh