University of Pittsburgh

University of Washington

Chieh-Li Chen

Joel Steven Schuman

Hiroshi Ishikawa

Chaim-Gadi Wollstein

Ruikang K Wang

Qinqin Zhang

Zhongdi Chu

The present invention is directed to systems and methods for generating virtually averaged optical coherence tomography (Oct.) images. An illustrative method can include receiving an image, identifying a first voxel of the image, and selecting a plurality of local voxels of the image. Each of the plurality of local voxels is within a defined region of the first voxel. The values of the plurality of local voxels can indicate an appearance of the local voxels in the image.

Image enhancement using virtual averaging

A five-index quantitative analysis of OCT angiograms is disclosed. One method of analyzing an anatomical region of interest of a subject includes acquiring vascular image data from the region of interest and generating a binary vasculature map from the vascular image data. A vessel skeleton map and vessel perimeter map are generated from the binary vasculature map. Based on the three generated maps, a vessel area density, vessel skeleton density, vessel perimeter index, vessel diameter index, and vessel complexity can be determined, in addition to detection of any flow impairment zones in the region of interest. These metrics can be used to detect and assess vascular abnormalities from multiple perspectives.

Systems and methods for quantitative assessment of microvasculature using optical coherence tomography angiography

The present disclosure is directed to systems and methods for normalizing an image of an eye among multiple optical coherence tomography (OCT) devices. The system can receive an OCT image and generate a normalized OCT image. The system is configured to normalize a sample density of the received image, normalize an amount of noise using a suitable noise reduction technique, normalize a distribution of signal amplitudes of the image, and then normalize a signal quality of the image. The resulting normalized image of the eye can then be used in the comparison among OCT images taken from multiple OCT devices.

Signal normalization among multiple optical coherence tomography devices

Growing community of inventors

Seattle, WA, United States of America

Chieh-Li Chen