Ajinomoto Co., Ltd.

Mitsubishi Chemical Corporation

Chie Koseki

Yoshihiro Usuda

Kazuhiko Matsui

Shinichi Sugimoto

Yousuke Nishio

Hiroyuki Kojima

Jun Nakamura

Keita Fukui

Takuji Ueda

Kenji Yamagishi

Yuji Joe

Makoto Murase

Ryusuke Aoyama

Shuichi Yunomura

Saori Kataoka

Akiko Sakamoto

Sanae Sato

Madoka Yonekura

Provided is a bacterium which is capable of producing an organic acid and is modified so as to have an enhanced 2-oxoglutarate dehydrogenase activity as compared with that of an unmodified strain. An organic acid such as succinic acid can be produced by culturing the bacterium.

Bacterium having enhanced 2-oxoglutarate dehydrogenase activity

An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the acetyl-CoA synthetase activity is increased.

Method for producing L-amino acid

Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product produced by any treatment of the bacterium with an organic raw material in a reaction solution containing a carbonate ion, a bicarbonate ion or carbon dioxide gas to thereby yield the desired succinic acid.

Process for production of succinic acid

The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacteriumssp.and methods of producing substances in organisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.

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Kawasaki, Japan

Chie Koseki