University of California

Fondazione Istituto Italiano Di Technologia

Fondazione Istituto Italiano Di Tecnologia

Università Degli Studi Di Parma

Università Degli Studi Di Urbino "carlo Bo"

Chiara Pagliuca

Daniele Piomelli

Tiziano Bandiera

Marco Mor

Daniela Pizzirani

Natalia Realini

Rita Scarpelli

Giorgio Tarzia

Fabio Bertozzi

Marco De Vivo

Anders Bach

Angelo Mario Reggiani

Andrea Nuzzi

Annalisa Fiasella

Stefano Ponzano

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.

Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments

Described herein are compounds and pharmaceutical compositions which inhibit N-acylethanolamine acid amidase (NAAA). Described herein are methods for synthesizing the compounds set forth herein and methods for formulating these compounds as pharmaceutical compositions which include these compounds. Also described herein are methods of inhibiting NAAA in order to sustain the levels of palmitoylethanolamide (PEA) and other N-acylethanolamines (NAE) that are substrates for NAAA, in conditions characterized by reduced concentrations of NAE. Also, described here are methods of treating and ameliorating pain, inflammation, inflammatory diseases, and other disorders in which modulation of fatty acid ethanolamides is clinically or therapeutically relevant or in which decreased levels of NAE are associated with the disorder.

Carbamate derivatives of lactam based N-acylethanolamine acid amidase (NAAA) inhibitors

The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.

Acid ceramidase inhibitors and their use as medicaments

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Arezzo, Italy

Chiara Pagliuca