Bracco Imaging S.p.a.

Chiara Brioschi

Alessandro Maiocchi

Fulvio Uggeri

Roberta Napolitano

Massimo Visigalli

Federica Buonsanti

Simona Ghiani

Luigi Miragoli

Giovanni Valbusa

Claudia Cabella

Lorena Pizzuto

Laura Orio

Francesco Blasi

The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence-guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.

Intra-operative imaging

The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.

Paramagnetic solid lipid nanoparticles (pSLNs) containing metal amphiphilic complexes for MRI

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Varedo, Italy

Chiara Brioschi