Yoshitomi Pharmaceutical Industries, Ltd.

Chiaki Tashiro

Ichiro Horii

Takeshi Kawakita

Yutaka Maruyama

Koretake Anami

Tomohiko Munakata

A hydrouracil compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein A represents --CH.dbd.CH--CH.sub.2 -- or --CH.sub.2 CH.sub.2 --, and R represents hydrogen or methyl. Such compounds are useful as analgesics.

Hydrouracil compounds

A polycondensation product of a germanium trihydroxide compound of the formula: ##STR1## wherein W is hydrogen, alkyl, halogen, alkoxycarbonyl, carboxy, aryl, cycloalkyl which may be substituted, cycloalkenyl, heteroaryl or a group of the formula: (R.sup.1)(R.sup.2)N-- wherein R.sup.1 and R.sup.2 are each lower alkyl or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form a group of the formula: ##STR2## wherein R.sup.3 is hydrogen, lower alkyl, phenyl which may be substituted, aralkyl, acyl, acylamino or heteroaryl, and X is --N.dbd., --CH.dbd. or ##STR3## A is a bond, alkylene, alkenylene, --CO--Y--, --CONH--Y--, --O--Y--, --S--Y-- or ##STR4## (Y is alkylene); and R is alkyl. Such compounds are useful as agents for treating immune diseases.

Organogermanium compounds

An imidazopyridine-spiro-piperi dine compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein X represents hydrogen, halogen or lower alkoxy, Y represents &gt;N-- or &gt;C.dbd.CH--, R.sup.1 and R.sup.2 both represent hydrogen or combinedly form a single bond, Alk represents lower alkylene, and R.sup.3 and R.sup.4 both represent hydrogen or combinedly form a single bond. Such compounds are useful as psychotropics.

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Yoshitomi, Japan

Chiaki Tashiro