Toyama Chemical Co., Ltd.

Chiaki Kutani

Isamu Saikawa

Shuntaro Takano

Kaishu Momonoi

Isamu Takakura

Kiyoshi Tanaka

Kenshin Hayashi

Seietsu Kuroda

Bunei Nagahashi

This disclosure relates to a novel process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.

Process for producing 7-(substituted)amino-3-substituted thiomethyl

This disclosure relates to a novel process for producing 7-(substituted)-amino-3-substituted thiomethyl-.DELTA..sup.3 -cephem-4-carboxylic acids which are intermediate products of cephalosporins being valuable antibacterial compounds for use in mammals including man.

Process for producing 7-(substituted)amino-3-substituted

The N,N-dimethylacetamide adduct of 7-[D(-)-.alpha.-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-.alpha.-(4-hyd roxyphenyl)acetamido]-3-[5-(1-methyl-1,2,3,4-tetrazolyl)thiomethyl]-.DELTA. .sup.3 -cephem-4-carboxylic acid, a process for the production thereof, and a process for producing said acid and a pharmaceutically acceptable salt thereof through said adduct.

Process for producing

Intermediate for cephalosporin type compound

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Funabashi, Japan

Chiaki Kutani