Shionogi Company Limited

The University of Tokyo

Tohoku University

Chiaki Fujikoshi

Yuuji Kooriyama

Sae Matsumoto

Shinji Suzuki

Yukio Tada

Tatsuhiko Ueno

Shuji Yonezawa

Yuusuke Tamura

Tetsuo Nagano

Manabu Katou

Nobuyuki Tanaka

Hirotatsu Kojima

Osamu Nureki

Akihiro Hori

Hiroshi Nishimasu

Takayoshi Okabe

Ryuichiro Ishitani

Yusuke Tateno

Terukazu Kato

Junken Aoki

Junji Yamane

Mitsuyasu Kawaguchi

Masahide Odan

Yuusuki Tamura

The present invention provides a compound of formula (1), wherein R, R, R, R, R, Rand Rare as defined in the description, which has an autotaxin inhibitory activity, a pharmaceutical composition comprising the compound as an active ingredient, and a method of prevention or treatment of a disease involving autotaxin, which is characterized by administering the compound. 

Fused pyrazole derivative having autotaxin inhibitory activity

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid &#x3b2; protein, for example, 

Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity

This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; Ris optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; Rand Rare each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R, R, Rand Rare each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.;a pharmaceutically acceptable salt or solvate thereof,which is useful for treating diseases induced by production, secretion and/or deposition of amyloid &#x3b2; protein.

Aminodihydrothiazine derivatives substituted with a cyclic group

This invention provides a compound of the formula (I): 

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Osaka, Japan

Chiaki Fujikoshi