Chang Gung University

Chang Gung Memorial Hospital, Linkou

Chia-Yu Yang

Chia-Hsun Hsieh

Kai-Ping Chang

Chih-Ching Wu

Chun-Nan Ouyang

Chiao-Rou Liu

Provided herein is a method for treating an oral cancer in a subject. According to embodiments of the present disclosure, the method comprises respectively obtaining a first and a second biological samples from a lesion site and a non-lesion site of the subject; respectively measuring the expression levels of CHEK1, PIK3CA, or PIK3CD in both biological samples by qRT-PCR thereby obtaining a first and a second expression level; determining the ratio of the first to the second expression level; and administering to the subject an effective amount of a checkpoint kinase 1 inhibitor when the ratio for CHEK1 is at least 1.7 or a phosphatidylinositol 3-kinase inhibitor when the ratio for PIK3CA is at least 2.4, or when the ratio for PIK3CD is at least 3.1.

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Taoyuan, Taiwan

Chia-Yu Yang