University of Cincinnati

Children's Hospital Medical Center

Chia-Ying James Lin

Stacey Gruber

Michael A Helmrath

John Van Aalst

Paulomi Ghosh

Alessandro De Alarcon

Patrick W Whitlock

Controlled release hydrogel formulations of one or more simvastatin metabolites 3'-hydroxy simvastatin (hSV), 6′-exomethylene simvastatin (eSV), 3′,5′-dihydrodiol simvastatin, 3′,5′-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.

Compositions and methods for treating defects in avascular cartilaginous tissue by directly administering one or more metabolites of simvastatin

Controlled release hydrogel formulations of one or more simvastatin metabolites 3'-hydroxy simvastatin (hSV), 6&#x2032;-exomethylene simvastatin (eSV), 3&#x2032;,5&#x2032;-dihydrodiol simvastatin, 3&#x2032;,5&#x2032;-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.

Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.

Microspheres containing decellularized donor tissue and their use in fabricating polymeric structures

Various aspects of the disclosure relate to a tracheal implant comprising (a) a trachea processed to comprise one or more incisions providing a helical configuration to the processed trachea; and (b) a subject-specific synthetic support.

Growing community of inventors

Mason, OH, United States of America

Chia-Ying James Lin