Morton-norwich Products, Inc.

Norwich Eaton Pharmaceuticals, Inc.

The Procter Gamble Company

The Proctor 'gamble Company

Chia-Nien Yu

Stanford S Pelosi, Jr

Ronald E White

George C Wright

Ralph L White, Jr

Gilles Yves Genain

Mark A Calcagno

Rachel Boujo

Disclosed are cyclic urea-containing compounds that are useful as antiarrhythmic and/or antifibrillatory agents. These compounds have the following structure: ##STR1## where X and Y are each independently selected from various cyclic moieties; R.sub.5 is a substituted or unsubstituted C.sub.2 alkyl (thus providing a 6-membered cyclic urea); and R.sub.1, R.sub.2, R.sub.3, R.sub.4, L, and A are as defined in the specification. Also disclosed are compositions containing the compounds and methods of treating humans or other mammals afflicted with cardiac arrhythmias and/or cardiac fibrillation by administration of the compounds/compositions.

Cyclic ureas useful as antiarrhythmic and antifibrillatory agents

The novel cyclic urethanes, and their pharmaceutically-acceptable salts and esters, described herein which are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein (a) X is a saturated or unsaturated, 5-, 6-, or 7-membered heterocycle or carbocycle;

Cyclic urethanes useful as antiarrhythmic and antifibrillatory agents

Urethane-containing amino steroids having the general chemical formula: ##STR1## wherein a, b, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.

Urethane-containing aminosteroid compounds

The cyclic ureas, and the pharmaceutically-acceptable salts and esters thereof, of the present invention are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein X, Y, A, L, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are defined as in the Specification.

The 4-oxocyclic ureas and the pharmaceutically acceptable salts and esters thereof, of the present invention are useful as antiarrhythmic and antifibrillatory agents and have the following general structure: ##STR1## wherein X, Y, A, L, R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are defined as in the specification.

4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents

Certain 5-phenyl-2-furoic acid hydrazides of the formula: ##STR1## wherein X represents 4-chloro, 4-fluoro, 3-trifluoromethyl or hydrogen, R.sub.1 represents hydrogen or methyl, R.sub.2 represents acetyl, isopropyl or methyl, and R.sub.1 and R.sub.2 taken together represent isopropylidene or 4-pyridinylmethylene are useful as anti-inflammatory agents.

5-phenyl-2-furoic acid hydrazides

2-[2-(5-Phenylfurfurylamino)ethyl]pyridines are useful as antihypertensive agents.

2-[2-(5-Phenylfurfurylamino)ethyl]pyridines

5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate is useful as an antidepressant agent.

5-(4-Aminophenyl)-2-thiophenecarboximidamide hydrochloride hemihydrate

5-(3-Trifluoromethylphenyl)-2-furancarboxylic acid 2-(1-methylethylidene)hydrazide is an effective skeletal muscle relaxant.

5-(3-Trifluoromethylphenyl)-2-furancarboxylic acid

5-(4-Chlorophenyl)-2-furanmethyl methyl ketone is useful as an antifungal agent.

5-(4-Chlorophenyl)-2-furanmethyl methyl ketone

2-[5-(4-Chlorophenyl)furfuryl]-1,3,-propanediol is useful as an anti-inflammatory and antifungal agent.

2-[5-(4-Chlorophenyl)furfuryl]-1,3,-propanediol

2-(5-p-Chlorophenyl-2-furyl)-5-methyl-1,3,4-oxadiazole is useful as an anti-inflammatory agent.

2-(5-p-Chlorophenyl-2-furyl)-5-methyl-1,3,4-oxadiazole

Certain 5-(4-nitrophenyl)-2-furanmethanamines are useful as anthelmintic agents.

5-(4-Nitrophenyl)-2-furanmethanamines derivatives

5-(p-Nitrophenyl)-2-furaldehyde 2-(2-hydroxyethyl)hydrazone is useful as an anti-inflammatory.

5-(p-Nitrophenyl)-2-furaldehyde 2-(2-hydroxyethyl)hydrazone

N,N-Dimethyl-5-phenyl-2-furamides are useful as anti-inflammatory agents.

Growing community of inventors

Norwich, NY, United States of America

Chia-Nien Yu