Naturewise Biotech and Medicals Corporation

Great Novel Therapeutics Biotech & Medicals Corporation

Gnt Biotech & Medicals Corporation

Novelwise Pharmaceutical Corporation

Chia-Nan Chen

Li-Ling Chi

Wei-Jan Huang

Chung-Yang Huang

Ye-Su Chao

Yi-Hong Wu

Jia-Shiong Chen

Cheng-Han Chou

Mu-Hsuan Yang

Sz-Hao Chu

Chia-Wei Lin

Yu-Chen Huang

Wei-Jung Chen

Jing-Shi Huang

Ai-Ling Chen

Chi-Yun Lee

Meng-Ju Tsai

Ying-Chen Yang

Ching-Yi Lin

Yu-Jung Liao

Wan-Yi Hsu

Chih-Hsiang Huang

Chiou-Ping You

Wan-Zo Ho

George Chung-Yih Chiou

Huan-Yu Lin

Ching-yi Lin

Chen Al-Ling

The present disclosure generally relates to compounds class I HDAC inhibitors, their production and applications. The compounds possess epigenetic immunomodulatory activities in the tumor microenvironment (TME) and thus inhibit growth of tumor cells.

Histone deacetylase inhibitors for immunomodulation in tumor microenvironment

The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.

Anticancer combination of chidamide and celecoxib salts

The invention relates to a method of removing immune suppression in a tumor microenvironment or stimulating an immune system against cancer cells, comprising administering to a subject a combination of a HDAC inhibitor and an NSAID in combination with an immune checkpoint inhibitor.

Pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy

The present invention is related to a method for treating an ocular disease, particularly a diabetes related ocular disease, comprising administering to a subject in need thereof an effective amount of a group of compounds having a structure of Formula A1, wherein the ocular disease is selected from the group consisting of proliferative vitreoretinopathy (PVR), uveitis, glaucoma and age related macular degeneration (AMD), and the diabetes related ocular disease is selected from the group consisting of diabetic retinopathy (DR) and diabetic macular edema (DME).

Methods for treating ocular diseases

The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.

PH-sensitive linkers for delivering a therapeutic agent

The invention relates to a method of using metal nanoparticle or metallic particle to promote neurite outgrowth and treat and/or prevent neurological disorders. Particularly, the method of the invention uses gold nanoparticles or gold particles to promote neurite outgrowth and treat and/or prevent neurological disorders.

Use of nano metal in promoting neurite outgrowth and treatment and/or prevention of neurological disorders

The present invention is directed to a novel use of prenylflavanone compounds for control of blood glucose and treatment or prevention of diabetes.

Prenylflavanone compounds for modulating diabetes

The invention provides a method of changing a ratio of 68 to 64 kDa protein of MRJP3 in a royal jelly, a method of producing a royal jelly comprising MRJP3 having a changed ratio of 68 to 64 kDa protein relative to a control royal jelly and the royal jelly produced thereform. Also provided is a method of promoting the growth of the larva of a queen bee comprising feeding the larva of the queen bee a royal jelly of the invention. Further provided is a method of producing bee larva, pupa and queen bees with sizes larger than normal.

Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly

The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).

Cinnamic compounds and derivatives therefrom for the inhibition of histone deacetylase

The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

Compounds for the inhibition of histone deacetylase

Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase

Disclosed is a compound capable of promoting the growth and development of neurons, the proliferation of neural stem cells and inducing the neural stem cells to differentiate into neurons, which is represented by a general formula as (I). The compound of the present invention can increase the survival rate of neural cells even at a low cellular density in a culture medium. The compound of the present invention can also promote the growth of neurons, which is revealed by the increase in the thickness, length and number of branches in the neurites (neural fibers). In addition, the compound of the present invention can be used to promote the development of neural stem cells and induce them to differentiate into neurons.

Compound for promoting the growth of neural cells

Growing community of inventors

Taipei, Taiwan

Chia-Nan Chen