Ampsource Biopharma Shanghai Inc.

Suzhou Youseen New Pharmacy Development Co., Ltd.

Chi Zhou

Qiang Li

Zhao Dong

Shixiang Jia

Xiong Feng

Jiyu Zhang

Danfeng Liu

Zhenyu Xuan

Yan Hua

Changxun Chen

The present disclosure relates to a dual-function protein for regulating blood glucose and lipid metabolism, wherein said dual-function protein comprises a human GLP-1 analog and human FGF21. In the present disclosure, provided is a method for preparing said dual function protein, and also provided is the use of said dual-function protein in the preparation of a biological substance for treating type 2 diabetes, obesity, dyslipidemia, fatty liver disease and/or metabolic syndrome. The dual-function protein provided in the present disclosure can synergistically regulate blood glucose and lipid levels in vivo, and satisfy multiple requirements for patients with type 2 diabetes such as lowering blood glucose, relieving hepatic steatosis, reducing body weight and improving metabolic disorders of circulating lipids.

Dual-function protein for lipid and blood glucose regulation

Growing community of inventors

Shanghai, China

Chi Zhou