Pharmaessentia Corporation

Chi-Yuan Chu

Wei-Der Lee

Wensen Li

Chan Kou Hwang

This invention relates to a process of stereoselectively synthesizing a &#x3b2;-nucleoside compound of formula (I): wherein R, R, and B are as defined in the specification; each of Rand R, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II): wherein R, R, and L are as defined in the specification, with a nucleobase derivative; and each of Rand R, independently, is H or fluoro.

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Yuanshan, Taiwan

Chi-Yuan Chu