Nexstar Pharmaceuticals, Inc.

Gilead Sciences, Inc.

Ec Technology LLC

Chi Tu

Bruce Eaton

Jeffrey T Beckvermit

Torin Dewey

Torin M Dewey

This invention discloses a method for the preparation of 2'-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.

Nucleoside modifications by palladium catalyzed methods

This invention discloses a method for the preparation of 2&prime;-modified nucleosides, using a palladium catalyst and an alkene functionalized with a heteroatom. Included in the invention are the novel pyrimidines and purines that can be prepared according to the method of the invention and oligonucleotides containing said modified pyrimidines and purines.

Purine nucleoside modifications by palladium catalyzed methods and compounds produced

Palladium catalyzed nucleoside modification methods using nucleophiles

This invention discloses an improved method for the preparation modified purine nucleosides at the 2-, 6- or 8-position of the purine ring, using a palladium catalyst.

Purine nucleoside modifications by palladium catalyzed methods and

This invention discloses a method for the preparation modified nucleosides using a palladium catalyst, a nucleophile and carbon monoxide.

Palladium catalyzed nucleoside modifications methods using nucleophiles

This invention discloses an improved method for the preparation modified purine nucleosides at the 2-, 6-, or 8-position of the purine ring, using a palladium catalyst.

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