Abbott Laboratories Corporation

Chi-nung W Hsiao

David R Hill

Ravi Kurukulasuriya

Steve Wittenberger

Daniel T Chu

Biswanath De

John F DeBernardis

Howard E Morton

Daniel A Dickman

Richard J Perner

William R Baker

Michael D Meyer

David M Stout

Qun Li

M Robert Leanna

Fatima Z Basha

Bruce W Horrom

Francis A Kerdesky

Stephen L Condon

Hormoz Mazdiyasni

Wei-Bo Wang

Thomas M Zydowsky

Maureen Ann McLaughlin

Yvonne Connolly Martin

Anne E Bailey

Todd S McDermott

John W Kebabian

Robert W Schoenleber

Michael P DeNinno

Stanley DiDomenico, Jr

The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

Process for the preparation of matrix metalloproteinase inhibitors

The instant invention provides a process for the selective N-formylation of N-hydroxylamines.

Process for the selective N-formylation of N-hydroxylamines

A process for the preparation of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.

Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid

Intermediates and a process for their preparation are disclosed which are useful for the preparation of a renin inhibiting compound of the formula: ##STR1## wherein R is a nitrogen-containing heterocycle which is bonded via a nitrogen atom to the sulfonyl group, R.sub.6 is hydrogen, alkoxy, halogen or loweralkyl, R.sub.7 is loweralkyl having 2 to 7 carbon atoms, and R.sub.8 is loweralkyl, cycloalkyl, or aryl or a pharmaceutically acceptable acid addition salt thereof.

Process for the preparation of a renin inhibiting compound

Novel compounds which are selective dopamine agonists are useful for treating disorders characterized by abnormal dopamine levels, such as Parkinson's Disease, as well as cardiovascular disorders.

Dopamine agonists

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Libertyville, IL, United States of America

Chi-nung W Hsiao