The University of Hongkong

Versitech, Inc.

Other

Samsung Electronics Co., Ltd.

Sichuan Knowledge Express Institute for Innovative Technologies Co., Ltd

Laboratory for Synthetic Chemistry and Chemical Biology Limited

Chi Ming Che

Chi Fai Kui

Chi Chung Kwok

Taotao Zou

Tsz Lung Lam

Raymond Wai-Yin Sun

Sin Ki Fung

Raymond Wai Yin Sun

Jing Yan

Chun Lam Kwong

Lok Fung Chow

Yoonhyun Kwak

Whail Choi

Yu Wang

Kai Li

Wai Hung Ang

Hai Feng Xiang

Pui Keong Chow

Tian Feng Chen

Kim Hei-Man Chow

Ka Chung Tong

Yik Sham Clive Chung

Zhen Fan Yang

Carrie Ka Lei Li

Annie Wai-Chee Kung

Mao Mao

So Ming Tong

Gang Cheng

Haixu Wang

Tingting Wang

Tingjie You

Wai Pong To

Dongling Zhou

Provides a type of gold(III) complex supported by tetradentate ligand having a structure of formula (I). The light-emitting device prepared by using the complex as a light-emitting layer material or dopant in the light-emitting device has a high external quantum efficiency, and a low efficiency roll-off. In addition, the preparation process of the tetradentate ligand provided in the present disclosure is simple and the yield is satisfactory. More importantly, the preparation reaction of the material is controllable and stable, and has a good reproducibility, and is suitable for industrial application.

Tetradentate ligands, gold(III) complexes, preparation method and use thereof

Methods for asymmetric cis-dihydroxylation ('AD') of quinones to produce cis-diols of quinones with high yield (i.e. a yield ≥30%) and high enantioselectivity (i.e. an enantiometric excess ≥30%) are disclosed. The method uses an iron-based catalyst, such as one or more Fe(II) complexes, as the catalyst, and can be performed under mild reaction conditions (e.g. a temperature ≤50° C. at 1 atom in open air). The method generally includes: (i) maintaining a reaction mixture at a temperature for a period of time sufficient to form a product, where the reaction mixture contains a quinone, one or more iron-based catalyst(s), and a solvent, and where the product contains a chiral cis-diol. Optionally, the method also includes adding an oxidant into the reaction mixture prior to and/or during step (i), such as a hydrogen peroxide solution.

Iron catalyzed highly enantioselective cis-dihydroxylation of quinones

Red-emitting platinum (II) Schiff base complexes with high emission quantum efficiency are prepared. These materials can be used to fabricate OLEDs.

Platinum (II) Schiff base complexes with increased emission quantum yield for red OLED applications

An asymmetric tetradentate metal complex of a N{circumflex over ( )}C{circumflex over ( )}C{circumflex over ( )}N comprising tetradentate ligand has a metal connected to binding sites which are connected to each other via three or four covalent bonds that can be either single or double bonds with bridging linkers reside between C{circumflex over ( )}C and C{circumflex over ( )}N moieties. These linkers result in three-dimension metal complexes with distorted square planar geometries. The four donor atoms coordinate to a metal center. Upon metal binding a 5-6-6 membered metallocycle is formed upon chelation including a first nitrogen donor bond, a first metal-carbon bond, a second metal-carbon bond, and a second nitrogen donor bond. The light emission from these metal complexes can be tuned by the ligand structure over the entire visible spectrum.

Spiro-containing platinum(II) emitters with tunable emission energies and syntheses thereof

Provided herein are Ir(III) complexes comprising N-heterocyclic carbene ligand, method of synthesis of the Ir(III) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Ir(III) complexes under both dark and light conditions. Also provided is a method of detecting the Ir(III) complex in a biological system. Also provided is a method of making the Ir(III) complex. The Ir(III) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.

Iridium (III) complexes containing N-heterocyclic carbene ligand, synthesis, and their use thereof in cancer treatment

Disclosed are conjugates, compositions, and methods that include or use one or more gold(III) porphyrin complexes. Preferred conjugates are gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. Preferred compositions and methods include or use such gold(III) porphyrin-PEG conjugates. Disclosed is a method for treatment of cancer comprising administering to a human in need of such treatment a composition containing a therapeutically effective amount of gold(III) porphyrin-poly(ethylene glycol) (PEG) conjugates. The gold(III) porphyrin-PEG conjugates can be in the form of nanostructures formed by self-assembly of the gold(III) porphyrin-PEG conjugates; or nanocomposites formed by encapsulation of other therapeutic agents by the nanostructures of gold(III) porphyrin-PEG conjugates.

Gold porphyrin-PEG conjugates and methods of use

Described are to tungsten(VI) emitters. These materials can be used to fabricate OLEDs.

Tungsten(VI) complexes for OLED application

Described herein are novel platinum(II) emitters. These materials show high emission quantum efficiency, a low self-quenching constant and are stable in thermal deposition process. Organic light-emitting diodes (OLEDs) fabricated from these materials can have pure green emission, high efficiency and low efficiency roll-off. The OLEDs can have a chemical structure of: 

Platinum (II) emitters for OLED applications

An organometallic compound represented by Formula 1: 

Organometallic compound, organic light-emitting device including organometallic compound, and diagnostic composition including organometallic compound

Provided herein are platinum complexes of Formula I: Also, provided are methods of making the platinum complexes of Formula I and apparatuses that include platinum complexes of Formula I. The apparatuses can include near infrared organic light emitting devices.

Platinum complexes and apparatuses thereof

Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.

Platinum (II) complexes containing N-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment

Disclosed are methods of using dsquare planar metal complexes containing tridentate &#x3c0;-conjugated ligands and ancillary ligand of N-heterocyclic carbene or di-phosphine ligand to target mismatched DNA. Targeting of mismatched DNA can be revealed by monitoring the differences in emission enhancement of metal complexes toward mismatched DNA and matched DNA; or the gradually heat release from isothermal titration calorimetry (ITC) when complexes bind toward mismatch DNA; or the significant increase in melting temperature of the mismatched DNA after adding complexes.

Method of targeting mismatched DNA using d8 square planar metal complexes

Described herein are compounds that are platinum emitters and, more particularly compounds that are platinum emitters of blue light and their applications in blue emitting organic light-emitting diodes (OLED). Also disclosed herein are devices that comprise the platinum emitters and methods of making and using the platinum emitters.

Platinum complexes for blue OLED application

The current invention relates to novel platinum(II) based organometallic materials. These materials show high emission quantum efficiencies and low self-quenching constant. Also provided are high efficiency, green to orange emitting organic light-emitting diode (OLED) that are fabricated using platinum(II) based organometallic materials as the light-emitting material. The organometallic materials of the invention are soluble in common solvents; therefore, solution process methods such as spin coating and printing can be used for device fabrication. The devices fabricated from these materials show low efficiency roll-off.

Platinum(II) complexes for OLED applications

Described herein are novel platinum(II) emitters. These materials show high emission quantum efficiency, a low self-quenching constant, and are stable in thermal deposition processes. Organic light-emitting diodes (OLEDs) fabricated from these materials can have pure green emission, high efficiency and low efficiency roll-off. The OLEDs can have a chemical structure of: 

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Hong Kong, China

Chi Ming Che