Arizona State University

Mayo Foundation for Medical Education and Research

Axim Biotechnologies, Inc.

Chi Lin

Jeffrey LaBelle

Marcus Smith

Jennifer Blain Christen

David Probst

Garrett Repp

Jonus Reyna

Mark Spano

Amnah Alkhan

Hongwu Jiang

Andrew Penman

Cael Muggeridge

Pierce Youngbar

Mackenzie Honikel

Susan Sheffield

Curtiss Cook

The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

Point-of-care apparatus and methods for analyte detections using electrochemical impedance or capacitance

Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.

Analyte detection using electrochemical impedance spectroscopy-based imaginary impedance measurement

Devices and methods capable of detecting glucose in saliva (FIG.). The devices feature a sensor having a substrate containing electrodes and one or more reagents on the electrodes. A detection device is operably coupled with the sensor to detect glucose based on measurement of an electrical parameter when electricity is applied to the electrode.

Saliva glucose measurement devices and methods

Growing community of inventors

Tempe, AZ, United States of America

Chi Lin