Chiesi Farmaceutici S.p.a.

Chi-Kit Woo

Monique Bodil Van Niel

Harry Finch

Carmelida Capaldi

Lilian Alcaraz

Bohdan Waszkowycz

John Montana

Jamie Knight

Disclosed are compounds having [1,2,4]triazolo[4,3-a]pyridine groups and pharmaceutically acceptable salts thereof. The compounds are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Kinase inhibitors

Compounds of formula (I) described herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

Compounds of formula (I) are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory wherein Ris a radical of formula (IA) or (IB) or (IC): 10 Y is &#x2014;O&#x2014; or &#x2014;S(O)&#x2014;wherein p is 0, 1 or 2; A is an optionally substituted cycloalkylene radical having 5, 6 or 7 ring atoms fused to a phenyl ring; and R, R3b and R4b are as defined in the claims. 

Urea derivatives and their therapeutic use in the treatment of, inter alia, diseases of the respiratory tract

Compounds of formula (I) are inhibitors of p38 MAP kinase, useful as anti-inflammatory agents in the treatment of inter alia, diseases of the respiratory tract wherein; Ris C-Calkyl, C-Ccycloalkyl, phenyl which is optionally substituted, 5- or 6 membered monocyclic heteroaryl which is optionally substituted, or a radical of formula (II) wherein n is 1 or 2, and Rand Rare independently H or C-Calkyl, or Rand Rtaken together with the nitrogen to which they are attached form a 6-membered heterocyclic ring optionally containing a further heteroatom selected from N and O; Y is &#x2014;O&#x2014; or &#x2014;S(O)&#x2014; wherein p is 0, 1 or 2; A is an optionally substituted divalent arylene radical, or a mono- or bicyclic heteroarylene radical, or a C-Cdivalent cycloalkylene radical having 5 or 6 ring atoms, or a piperidinylene radical wherein the ring nitrogen is linked to RNHC(&#x2550;O)W&#x2014;; W is a bond, &#x2014;NH&#x2014; or &#x2014;C(R)(R), wherein Rand Rare independently H, methyl, ethyl, amino, hydroxyl or halo; and Ris a radical as defined in the claims. 

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Harlow, United Kingdom

Chi-Kit Woo