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Centre National De La Recherche Scientifique

Universitè De Montpellier

Institut Curie

Université Montpellier 2 Sciences Et Techniques

Chi Hung Nguyen

Emile R Bisagni

David Grierson

Anne-Marie Aubertin

Claude Monneret

Valerie Dolle

Jamal Tazi

Christian Rivalle

Michel Legraverend

Johann Soret

Philippe Jeanteur

Val&eacute;rie Dolle

Michel Ventura

Marie-Line Andreola

Andre Kirn

Laura Tarrago-Litvak

The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromosome 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atorphy which affects the SMN (Survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.

Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process

3-(amino-or aminoalkyl) pyridinone derivatives and their use for the treatment of HIV related diseases

The present invention is concerned with 3-(amino- or aminoalkyl)pyridinone derivatives which inhibit the reverse transcriptase of the Human Immunodeficiency Virus (HIV). It relates moreover to the use of such compounds for treating HIV-related diseases. Furthermore it relates to a process for the preparation of these compounds.

3-(Amino- or aminoalkyl)pyridinone derivatives and their use for the treatment of HIV related diseases

4-Aryl-thio-pyridin-2(1H)-ones, medicines containing them and their uses

Growing community of inventors

Antony, France

Chi Hung Nguyen