Supertex, Inc.

The Chinese University of Hong Kong

Chi Chun Wong

Terasuth Ko

Jun Yu

Joseph Jao Yiu Sung

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the SCNN1B gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating gastric cancer by increasing SCNN1B gene expression or activity.

Biomarker SCNN1B for gastric cancer

A regulated cascode current source has a current source circuit. A level shifter circuit is coupled to the current source circuit. The level shifter circuit has a circuit for independently controlling a voltage on a cascode node.

Wide-band wide-swing CMOS gain enhancement technique and method therefor

A switched-capacitor sample/hold circuit and method having reduced slew-rate and settling time requirements provides for lower-cost and/or lower-power implementation of sample/hold circuits and/or reduced error due to amplifier characteristics. The switched-capacitor sample/hold circuit incorporates a pair of capacitors that are alternatively and mutually-exclusively switched between an input sample position and an amplifier hold position, providing a dual sampled amplifier output signal that has reduced transitions at each sample interval. An alternative embodiment of the sample/hold circuit incorporates a fully-differential amplifier having a differential input and a differential output. Four capacitors are employed forming two of the dual sampled switched-capacitor circuits, one in each negative feedback path (inverted output to non-inverting input, non-inverted output to inverting input) of the amplifier. The two dual sampled switched-capacitor circuits are referenced to each other, providing fully differential operation and cancellation of error due to charge injection.

Growing community of inventors

Hong Kong, China

Chi Chun Wong