Posco

Postech Foundation

Korea Materials & Analysis Corporation

Sugentech, Inc.

K-mac Bio Center Corp.

Industrial Cooperation Agency

Chi-Bom Chae

Kyung-Tae Kim

Yong Song Gho

Jong Hun Kang

Chan Hyun Na

Sewook Hwang

Seung-Pil Yang

Soon Jin Oh

Sanghee Jeon

Seong-Suk Hur

Dong-Goo Bae

Byung Oh Kwon

Disclosed is a method for detecting nucleic acids by promoting branched DNA complex formation. The target nucleic acid detection signal and sensitivity can be dramatically increased by promoting self assembly of branched DNA between a plurality of amplified DNA targets and a single-chain oligonucleotide probe, by means of the integrated implementation of PCR, thermal denaturation and hybridization in a single reaction mixture.

Method for detecting nucleic acids by promoting branched DNA complex formation

This invention relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules. The invention includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide genetic diagnosis in one step.

One step diagnosis by dendron-mediated DNA chip

The disclosure relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules of DNA viruses. The disclosure includes DNA chips with probes immobilized via a dendron-mediated linkage in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide genetic diagnosis in one step.

Dendron-mediated DNA virus detection

The present invention relates to a VEGF polypeptide that binds to A&#x3b2;. The present invention also relates to a compound that sequesters A&#x3b2;. And conversely, the invention relates to a compound that sequesters VEGF. Thus, the present invention also relates to a method of screening for a compound that inhibits the binding of VEGF to A&#x3b2;, and thus relates to prevention and treatment of Alzheimer's Disease.

Methods of contacting &#x3b2; amyloid protein with VEGF

Disclosed is a method of using a compound as an inhibitor for &#x3b2;-secretase, wherein the compound is capable of binding to the site within the &#x3b2;-secretase recognition and/or cleavage site on amyloid precursor protein to specifically inhibit the &#x3b2;-secretase's activity to cleave amyloid precursor protein with maintaining its activities to other substrates. Further, the present invention relates to inhibitors of amyloid precursor protein (APP) processing which bind to the site within the &#x3b2;-secretase or &#x3b3;-secretase cleavage and/or recognition site on amyloid precursor protein.

Inhibitors of amyloid precursor protein processing

Growing community of inventors

Seoul, South Korea

Chi-Bom Chae