Johnson Matthey Public Limited Company

Chester Sapino

Bogdan Mudryk

Jen-Sen Dung

Alice Sebastian

Joydeep Kant

Matthew P McWilliams

James Guro

A process for the preparation of thebaine, its salts such as the bitartrate, and analogues thereof, together with a novel intermediate useful in said process are disclosed. Thebaine bitartrate is itself useful in the preparation of oxycodone; analogues are useful in the preparation of analogous 14-hydroxymorphinones.

Preparation of opiates, intermediates and uses of salts

A process for the preparation of a nitrosourea derivative, in particular 1,2-bis(2-chloroethyl)-1-nitrosourea, comprises reacting a non-nitrosated urea derivative with a metal nitrite in a two-phase solvent system comprising an aqueous acid and a non-miscible organic solvent.

Process for the preparation of nitrosourea compounds

Methyl .alpha.-phenyl-2-piperidine acetate (free base) is disclosed as a crystalline solid, together with a method for its preparation; its use in medicine, in particular as a stimulant for the central nervous system; and pharmaceutical formulations comprising the compound, particularly transdermal patches.

Solid .alpha.-phenyl-2-piperidine acetate free base, its preparation and

A method for removing residual organic solvents from a bulk substance, for example from a pharmaceutical drug substance, comprises drying the bulk substance in the presence of water vapor, such that the residual organic solvent molecules are displaced with water vapor molecules.

Method for removal of residual organic solvents and use thereof in

A novel process for preparing narcotic analgesics such as hydrocodone and hydromorphone using catalytic amounts of homogeneous organometallic complexes is disclosed.

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Sewell, NJ, United States of America

Chester Sapino