Smithkline Corporation

Chester Rhodes Willis

Kenneth M Snader

Lawrence William Chakrin

Pharmaceutical compositions comprising a substituted 4,6-dihydroxy-2H-pyran-2-one and methods of inhibiting the antigen-antibody reaction by administering said compositions.

Method of treating asthma with 4,6-dihydroxy-2H-pyran-2-ones

Pharmaceutical compositions comprising a substituted 3-cinnamoyl-2H-pyran-2,6(3H)-dione and methods of inhibiting the antigen-antibody reaction by administering said compositions.

Substituted 3-cinnamoyl-2H-pyran-2,6(3H)-diones

Substituted 2H-pyran-2,6(3H)-dione derivatives useful in the treatment of allergic conditions are prepared by reaction of 3,5-diacetyl-4,6-dihydroxy-2H-pyran-2-one with an appropriate aniline.

Substituted 2H-pyran-2, 6(3H)-dione derivatives

Substituted 2H-pyran-2,6 (3H)-dione derivatives useful in treatment of

Substituted 3-(1-aminoethylidene)-5-cinnamoyl-2H-pyran-2,6(3H)-diones useful as inhibitors of certain antigen-antibody reactions, particularly in alleviating allergic manifestations such as asthma, are prepared by reaction of a 3-(1-aminoethylidene)-5-acetyl-2H-pyran-2,6(3H)-dione with an appropriately substituted benzaldehyde.

Substituted 3-(1-aminoethylidene)-5-cinnamoyl-2H-pyran-2,6(3H)-diones

Pharmaceutical compositions comprising a substituted 3-cinnamoyl-2H-pyran-2,6(3H)-dione and methods of inhibiting the antigen-antibody reaction by administering said compositions. Certain of the 3-cinnamoyl-2H-pyran-2,6(3H)-diones are novel compounds per se.

Growing community of inventors

Kingston, Jamaica

Chester Rhodes Willis