Leica Biosystems Melbourne Pty Limited

Genea IP Holdings Pty Limited

Genea Limited

Chester John Henderson

Eduardo Vom

Andrew McLellan

Craig Matthew Lewis

Mark Dockrill

Simon Harris

Tammie Kim Roy

Stuart Elliot

Peter Riddell

Jonathan McKinlay

George Goris

Andrew C Jenkins

Benedict John Stewart-Steele

Ben Hobbs

Teija Tuulikki Peura

Susanna Brandi

Sam Gason

John McCormack

Ian Donald Reilly

Stephen Collings Morris

Richard John Louis Gardner

Timothy Brett McDonald

Ian Emil Sohn

Neville John Farmer

The present application is directed to the processing of a biological sample into its constituent components for use in ART and includes introducing a sample into a first volume disposed adjacent a second volume including buffer solution, wherein the first and second volumes are adapted for fluid communication therebetween, selectively separating the first volume from the second volume with a movable closure member disposed therebetween, wherein the step of selectively separating the first volume from the second volume includes moving the closure member so that a fluid communication aperture is formed by one or a combination of the closure member or the closure member in combination with the first and second volumes to allow fluid communication between the first volume and the second volume such that motile cells migrate from the sample in the first volume to the buffer solution in the second volume.

Method and system for processing a biological sample

A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region, wherein the apparatus includes a locating means to locate the substrate; a cover locating means for locating and moving the cover with respect to the substrate; a fluid dispensing means for dispensing fluid into the reaction chamber; and a draining mechanism; wherein the draining mechanism includes wicking means.

Biological reaction apparatus with draining mechanism

An apparatus for micromanipulation of biological material, includes a vessel () having a reservoir () wherein the vessel has a channel () formed in a portion of the reservoir, the channel including an intermediate restriction () dimensioned to resist passage of the biological material but allow passage of liquid treatment solutions.

Micromanipulation and storage apparatus and methods

A method of cryopreservation of biological material includes the steps of providing an apparatus including a vessel having a reservoir wherein the vessel has a channel formed in a portion of the reservoir, the channel including an intermediate restriction dimensioned to resist passage of the biological material but allow passage of liquid treatment solutions, and the channel including sub-reservoirs at either end of the restriction; introducing the biological material into a reservoir region of the apparatus for capture in a channel region of the vessel; irrigating and draining the biological material with a series of vitrification solutions introduced into a first of the sub-reservoirs and removed from a second of the sub-reservoirs; final draining the irrigation solutions from the vessel; and vitrifying the vessel and captive biological material.

A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station.

Device and method for tissue handling and embedding

A tissue handling apparatus is provided comprising a support and a locator, for processing and embedding tissue samples. The support and cover form a chamber, within which a tissue sample is oriented prior to processing. After processing, the tissue sample within the chamber is embedded and the locator is removed, leaving the tissue sample correctly oriented in embedding material, mounted to a support, ready for microtoming.

Method and apparatus for handling tissue samples

A cover for a substrate including: a body defining a cavity, for positioning over the substrate to form a reaction chamber; and a projection extending from the body to define a fluid reservoir, when the cover is fitted to the substrate, the fluid reservoir being in fluid communication with the cavity.

Microscope slide cover with integrated reservoir

A biological reaction apparatus for receiving at least one substrate having a sample located in a sample region, and a separate cover, such that a reaction chamber is formed between the cover and substrate over the sample region. The apparatus includes a substrate locator for locating the substrate; a cover locator for locating and moving the cover with respect to the substrate; a fluid dispenser for dispensing fluid into the reaction chamber; and a draining mechanism which includes a wick.

Fill fluid for biological reaction apparatus with draining mechanism

A mould and tissue cassette for automated embedding of tissue, and a method of operation are disclosed. The mould attaches to the cassette prior to embedding, and fits into a rack. The rack supports the mould holding the tissue cassette when the mould and cassette are in a first position. When the mould and cassette are moved to a second position, a projection on the rack separates the mould from the cassette, to facilitate easy removal. Also disclosed is a mould for a tissue cassette having projections for holding the mould to a rack, so that the tissue cassette is not in contact with the mould.

Devices and methods for tissue handling and embedding

A slide holder () for use with a microscope to accurately locate a slide () in position under the microscope has a pivotal lever () having a clamping and locating portion () with abutments () and () which bear on respective edges of the slide when it is in the clamped position. Further abutments () on a fixed angular plate () locate the other edges of the slide. The slide holder is adapted for mounting on a slide translation stage of a slide loader () which includes a stationary sensor block () positioned to engage the lever () when the slide holder moves from its inspection or scanning position under the microscope to a loading/unloading position. The slide translation stage includes a robotic head for lifting and depositing slides and the translation stage includes a bar code reader to read a bar code on the slide.

Growing community of inventors

Collingwood, Australia

Chester John Henderson