Ariad Gene Therapeutics, Inc.

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Wu Yang

Dennis Alan Holt

Leonard W Rozamus

Methods and materials involving 28-epirapamycin analogs are disclosed.

28-epirapalogs

Rapamycin derivatives containing substituents at C-28 in the epi orientation relative to rapamycin are disclosed, together with methods for their preparation and use, e.g. for regulation of biological phenomena in engineered cells. The compounds may contain optional additional modifications relative to rapamycin, as disclosed herein.

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Watertown, MA, United States of America

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