Schering Corporation

Cheryl A Alaimo

Nicholas I Carruthers

Neng-Yang Shih

Pauline C Ting

Gregory A Reichard

Ashit K Ganguly

John J Piwinski

Robert G Aslanian

Kevin D McCormick

Bandarpalle B Shankar

Pietro Mangiaracina

Michael P Kirkup

James M Spitler

Andrew Lupo, Jr

Brian J Lavey

Compounds within the genus represented by the structural formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; ##STR2## R.sup.4 is methyl or ethyl; and Z is substituted piperidinyl.

Substituted oximes as neurokinin antagonists

Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or3;

Substituted oximes, hydrazones and olefins as neurokinin antagonists

Compound represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: a is 0, 1, 2 or 3;

The invention relates to compounds of the formula ##STR1## wherein X, i, j, n, n', A, A', R.sub.2, R.sub.3, and U are as described herein. The compounds of the invention are NK.sub.1 or NK.sub.2 or NK.sub.3 receptor antagonists and as such are useful in the treatment of diseases such as asthma.

Piperidine derivatives as neurokinin antagonists

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Somerset, NJ, United States of America

Cheryl A Alaimo