Battelle Memorial Institute

Cherry Gupta

Anthony David Duong

Danielle J Huk

Kenneth R Sims, Jr

Stephanie Kute

Jacob Lilly

Andrea D Mccue

Mike Koeris

Michael Sandor Koeris

Craig Bartling

Rachel R Spurbeck

Miguel D Pedrozo

Zachary R Shank

Julianne Np Smith

Ashlee J Colbert

Nickolas R Andrioff

Michael Riedl

James Ha

Michael Wagner

Emma K Schmitz

Jacqueline Grible

Caleb T Hillrich

Shannon D Miller

Joanna L Hoy

The disclosure relates to block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, for delivering nucleotides that encode polypeptides.

Polymer nanoparticle compositions for in vivo expression of polypeptides

The present disclosure is directed to compositions and methods that use the principles of DNA origami to package and archive data stored in multiple indexed DNA oligonucleotides. These structures allow for selective physical data access and retrieval from a molecular pool of DNA origami (DNAO) nanostructures comprising the data bearing oligonucleotides.

Use of DNA origami nanostructures for molecular information based data storage systems

The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

Polymer nanoparticle and DNA nanostructure compositions and methods for non-viral delivery

The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.

Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

Growing community of inventors

Columbus, OH, United States of America

Cherry Gupta