Other

Pfizer Corporation

Syntex (u.s.a.) Inc.

Pharmacia Corporation

Cherng-chyi Fu

Brian H Vickery

Eric J Benjamin

Lynda M Sanders

Su Il Yum

Philip L Felgner

William A Lee

Anthony C Allison

Michael S Zamloot

Andrei Blasko

Deborah M Lidgate

Noelene E Byars

De-Hwa Chao

Linda C Foster

Novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles are disclosed. Exemplary opioids include oxycodone, oxymorphone, hydrocodone, and hydromorphone, including as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less and or equal to 10&#x3bc; or less than or equal to 20&#x3bc; are disclosed. Methods for micronizing an opioid to provide stabilized micronized opioid particles are also disclosed.

Micronized opioid compositions having a specific particle size distribution

Pharmaceutical compositions of biologically active polypeptides in powder form suitable for nasal administration, comprising a therapeutically effective amount of a biologically active polypeptide and a water-soluble polysaccharide.

Intranasal administration of polypeptides in powdered form

Intranasal administration of LHRH polypeptides in powdered form

This invention is directed to an adjuvant composition in the form of an emulsion which is comprised of an emulsion-forming amount of a non-toxic tetra-polyol or of a POP-POE block polymer and an immunopotentiating amount of a muramyldipeptide of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, where R and R.sub.1 are each independently H or acyl of 1 to 22 carbon atoms, R.sub.2 is optionally substituted alkyl or optionally substituted aryl, R.sub.3 is H, alkyl, or aryl, R.sub.4 is H or lower alkyl, X is L-alanyl, L-.alpha.-aminobutyryl, L-arginyl, L-asparginyl, L-aspartyl, L-cysteinyl, L-glutaminyl, L-glutamyl, glycyl, L-histidyl, L-hydroxyprolyl, L-isoleucyl, L-leucyl, L-lysyl, L-methionyl, L-ornithinyl, L-phenylalanyl, L-prolyl, L-seryl, L-threonyl, L-tyrosyl, L-tryptophanyl, or L-valyl, and Y is D-glutamine, D-isoglutamine or D-isoasparagine. This invention is also directed to a vaccine containing an antigen and an adjuvant composition of the invention. This invention is also directed to a process of preparing an adjuvant composition and a vaccine of the invention. This invention is also directed to a kit for extemporaneous preparation of an adjuvant composition and a vaccine of the invention.

Vaccine adjuvant

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Saratoga, CA, United States of America

Cherng-chyi Fu