Randox Laboratories Limited

Cherith N Reid

John Victor Lamont

Mark William Ruddock

Stephen Peter Fitzgerald

Kathleen Williamson

Peter Fitzgerald

Kate E Williamson

Ricardo De Matos Simoes

Frank Emmert-Streib

Mark W Ruddock

John Lamont

The present invention provides a method and a solid state device for identifying the presence of urothelial cancer in a patient comprising assigning the subject to a sub-population according to smoking habits, measuring the level of each biomarker of a panel of biomarkers in one or more samples obtained from the subject; and correlating the measured levels of the panel of biomarkers with the likelihood of the subject having urothelial cancer such that the subject can be classified as having urothelial cancer or as being a control.

Diagnosis of urothelial cancer

The invention provides a method of defining the likelihood of a subject having bladder cancer, comprising the steps of:

Diagnosis and risk stratification of bladder cancer

Methods for the detection of, or the risk of, bladder cancer in a patient, comprising assaying for the presence of a combination of at least two biomarkers selected from CEA, VEGF, IL-8, NGAL, NSE, IL-2, EGF, TM, d-Dimer, MMP-9, IL-6, IL-4, MMP-9/NGAL, FAS, CRP, TUP and NMP22 in one or more samples isolated from a patient wherein detecting the presence of a combination of at least two biomarkers in the one or more samples indicates the presence or risk of bladder cancer.

Method for detection of, or the risk of, bladder cancer

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Crumlin, United Kingdom

Cherith N Reid