Nektar Therapeutics

Cherie F Ali

Mary J Bossard

Yujun Wang

Xiaofeng Liu

Deborah H Charych

Ping Zhang

Harold Zappe

C Simone Jude-Fishburn

Dennis G Fry

Dawei Sheng

Haim Moskowitz

Steven O Roczniak

Christine Taylor Brew

Elizabeth Louise Minamitani

Elizabeth Minamitani

Christine Brew

Conjugates of an interleukin-2 ('IL-2') moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the non-peptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

Conjugates of an IL-2 moiety and a polymer

Conjugates of an interleukin-2 ('IL-2') moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Polymer conjugates of therapeutic peptides

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Burlingame, CA, United States of America

Cherie F Ali