Mersana Therapeutics, Inc.

Nicox S.a.

Nitromed, Inc.

Asana Biosciences, LLC

Cheri A Stevenson

Aleksandr V Yurkovetskiy

Mao Yin

Timothy B Lowinger

Joshua D Thomas

Charles E Hammond

Patrick R Conlon

Natalya D Bodyak

David S Garvey

Xinqin Fang

Subhash P Khanapure

Richard A Earl

Maiko Ezawa

Dmitry R Gumerov

Ramani R Ranatunge

Shiow-Jyi Wey

L Gordon Letts

Chia-En Lin

Joseph David Schroeder

Stewart K Richardson

Ricky D Gaston

Venu Reddy Gurijala

Russell Colyn Petter

Roger Astbury Smith

Upul Keerthi Bandarage

Nitin Krishnaji Damle

Bingfan Du

John J Kane

Laura C Akullian

Mariya Kozytska

Venu R Gurijala

John Henry Van Duzer

Eugene W Kelleher

Manuel Worcel

Shuyi Tang

Gui Liu

Ramani R Ranatunga

Carolina B Cabral

Dimitry R Gumerov

Ahmed Hilmy

Roger A Smith

Nitin K Damle

The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.

Peptide-containing linkers for antibody-drug conjugates

A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

Protein-polymer-drug conjugates

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight&#x2264;5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently an Auristatin compound. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

The present disclosure relates generally to derivatives of pyrrolobenzodiazepines and antibody-drug conjugates thereof and to methods of using these conjugates as therapeutics and/or diagnostics.

Pyrrolobenzodiazepines and conjugates thereof

An auristatin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently an auristatin compound having a molecular weight &#x2264;5 kDa. Land Lare distinct linkers connecting the auristatin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-auristatin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

Auristatin compounds and conjugates thereof

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight &#x2266;5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

Growing community of inventors

Haverhill, MA, United States of America

Cheri A Stevenson