Hanmi Pharm. Co., Ltd.

Cheol-Kyung Kim

Gwan-Sun Lee

Young-Kil Chang

Gha-Seung Park

Chul-Hyun Park

Jae-Heon Lee

Hong-Sun Kim

High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.

Crystalline acid salts of cefdinir and process for preparing cefdinir using same

A 3-(Z)-propenyl cephem compound is selectively prepared by reacting a phosphoranylidene cephem compound with acetaldehyde in the presence of a base in a solvent mixture comprising diethyl ether, formula (I), wherein R is a carboxyl protecting group; Ris hydrogen or RCHCO&#x2014;; and Ris ethyl, 2-thiophenyl, phenyl, p-hydroxyphenyl or phenoxy 

Process for the selective preparation of 3-(z) propenyl-cephem compound

7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfonic acid:

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Namyangju-si, South Korea

Cheol-Kyung Kim