Chosun University

Cheol-Hee Choi

Hoon Cho

Young-Sook Moon

Ju-Hee Han

Kyoung-In Lee

Hyun-Jung Kim

Ji-Won Han

Ying Wu

Provided is a use ofextract as an agent for preventing and treating benign prostatic hyperplasia, and more particularly, a composition for preventing and treating benign prostatic hyperplasia and a functional health food for preventing and reducing the effects of benign prostatic hyperplasia, in which the composition and food include, as an active ingredient, aextract or a compound which is isolated from the extract and then purified.

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Provided is a 15-PGDH activity adjusting function of aextract. More specifically, since it has been confirmed that theextract has an outstanding effect in suppressing 15-PGDH activity and so increasing PGE, a composition of the present invention which contains theextract as an active ingredient has the advantage of being able to be used for producing a functional health food and a therapeutic agent for a disease associated with PGE.

The present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and the uses thereof. More specifically, the present invention relates to novel thiazolidinedione derivatives expressed by the following formula (I) and a pharmaceutical composition comprising the same. The novel thiazolidinedione derivatives of formula (I) according to the present invention can be effectively used for the prevention or treatment of cardiovascular disease, gastrointestinal disease and renal disease by inhibiting the activity of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that decomposes prostaglandins as well as useful for the prevention of hair loss and the stimulation of hair growth, and osteogenic stimulation and wound healing.

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Gwangju, South Korea

Cheol-Hee Choi