Micromedmark Biotech Co., Ltd.

Jiangsu Micromedmark Biotech Co., Ltd.

Jiangsu Mingma Biotech Co., Ltd.

Beijing University of Posts and Telecommunications

State Grid Jiangsu Electric Power Company

Jiangsu Electric Power Research Institute Co., Ltd.

Lenovo (beijing) Limited

Nanjing University

State Grid Corporation of China

State Grid Jiangsu Electric Power Co., Ltd. Research Institute

State Grid Jiangsu Electric Power Company Research Institute

Jiangsu Mircromedmark Biotech Co., Ltd.

Chenyu Zhang

Ke Zeng

Junfeng Zhang

Hongwei Gu

Xi Chen

Hongwei Liang

Yi Ba

Haijin Li

Wei Zheng

Jin Wang

Xiangming Wen

Mingming Shi

Cheng Fang Wang

Rui Liu

Jian Liu

Cheng Wang

Jinggang Yang

Zhaoming Lu

Yubo Yuan

Xihan Li

Jiangning Chen

Hongjie Zhang

Zhengying Wang

Uzair Ur-Rehman

Cong Li

Liming Li

Shu Chen

Yi Bai

Yuan Yin

Jing Li

Lei Dong

Lili Guo

Xiaodong Yuan

Qun Li

Luhan Wang

Danqing Liu

Ruihuang Liu

Tianfu Zhang

Yunlong Jiang

Yinping Zhang

Xing Cai

Xueliang Wang

Zhi Hong

Zhen Zhou

Chunni Zhang

Minghui Cao

Yujing Zhang

Xuefeng Ge

Huiyu Miao

Qi Zhou

Ye Chen

Xiuting Hu

Xinyan Zhou

The present invention provides a use for a small nucleolar RNA (snoRNA) or a detection reagent thereof, for use in detection of a servitization state of cells; moreover, detection and regulating methods for the snoRNA are established.

Molecular marker detection and regulating methods in de-servitization state of cells

A speech processing method includes obtaining first speech information from a user, determining one or more similar speech segments in the first speech information and deleting one or more similar frames each of the one or more similar speech segments to obtain second speech information, and analyzing the second speech information to determine a user intent corresponding to the first speech information. A duration of the first speech information exceeds a preset analysis duration threshold, and a duration of the second speech information does not exceed the preset analysis duration threshold.

Speech processing method and apparatus

The present invention discloses a method and apparatus for photovoltaic DC direct-fed power generation based on controllable power supply. According to the present invention, the photovoltaic cells are directly connected to the DC microgrid, and the DC bus voltage is flexibly regulated by the controllable power supply in the DC microgrid to enable the photovoltaic cells to operate at the maximum power, thus eliminating the need for a DC interface converter when the photovoltaic cells are connected to the DC bus and reducing the cost and size of the distributed PV power generation system.

Method and apparatus for photovoltaic DC direct-fed power generation

Provided are an EGFR gene expression-suppressing siRNA, a precursor sequence of same, and uses thereof.

EGFR gene expression-suppressing siRNA, precursor of same, and applications thereof

Embodiments of the present disclosure disclose a method, an apparatus, and an electronic device for an absolute time synchronization, the method comprising: receiving, from a baseband processing chip, a first timing signaling and a first real system frame information of the received first timing signaling, the first timing signaling comprising a first absolute time corresponding to local time of a base station at time of transmission of the first timing signaling, and a first reference system frame information used by the base station for transmitting the first timing signaling; calculating a first time delay between the base station and the terminal based on at least the first absolute time, if the first real system frame information is consistent with the first reference system frame information; receiving, from the baseband processing chip, subsequent timing signalings and corresponding second real system frame information used by the base station for transmitting the subsequent timing signalings to the terminal, the subsequent timing signalings each comprising a second absolution time corresponding to the local time of the base station at time of transmission of the subsequent timing signaling and a second reference system frame information used by the base station for transmitting the subsequent timing signaling; for each of the subsequent timing signalings, determining a time delay adjustment value between the subsequent timing signaling and the first timing signaling based on at least the first time delay and the second absolute time, if the second real time system frame information is consistent with the second reference system frame information; and after a number of the received subsequent timing signalings reaches a target number, obtaining an absolute time information based on the time delay adjustment values corresponding to the target number of subsequent timing signaling; wherein the absolute time information is used to synchronize time of the terminal to time of the base station.

Methods, apparatus and electronic devices for absolute time synchronization

Disclosed is a fault current controller for a direct current power grid, which includes a primary circuit and a controller. The primary circuit includes an inductor, a filter capacitor, a resistor, an IGBT switch, a diode, a contactor and a Hall current sensor. The inductor, a first resistor and a second contactor are connected in series and are connected to a first contactor in parallel. A first branch including a second resistor and a first diode, a second branch including a third resistor and a second diode, and the inductor are connected in parallel; the filter capacitor, the IGBT switch and the first resistor are connected in parallel. The Hall current sensor is arranged in the series circuit. The controller controls the IGBT switch and the two contactors in the primary circuit to form different on-off combinations.

Fault current controller for a direct current power grid

Embodiments of the present disclosure disclose a timing method and a device for a mobile network. The mobile network comprises: a master clock, a first network, a first network device, and a second network device. The first network device acquires timing information from the master clock through the first network, calibrates a second network device clock of the second network device according to the timing information, and calibrates a terminal clock of a terminal device according to the calibrated second network device clock.

Timing method for mobile network, device, and readable storage medium

The present invention discloses an siRNA that inhibits K-RAS gene expression, and the precursor sequences and applications thereof. The K-RAS siRNA and its precursor sequences provided by the present invention can efficiently inhibit the expression of the K-RAS gene, and in vivo experiments have shown that the K-RAS siRNA has a certain inhibitory effect on tumours highly expressing K-RAS. The precursor of the siRNA of the invention and its vector can form a stable siRNA that functions in a host.

K-RAS gene expression-suppressing siRNA, precursor of same, and applications thereof

Provided are non-small cell lung cancer markers and the use thereof in diagnosing and monitoring diseases in vitro. The non-small cell lung cancer markers include at least one of 26 selected detectable mature microRNAs existing stably in human serum or plasma. Also provided are probe combinations, a kit and a biochip for detecting the non-small cell lung cancer markers. The invention further provides a method for detecting the said lung cancer markers. The method in the present invention enables extensive detection spectrum, high sensitivity, low cost, convenient sample taking and preservation. The method can be applied in the general survey of disease, solves problems of low specificity and sensitivity encountered with previous single markers, and increases significantly the clinical detection rate of diseases. The methods provide an effective means for diagnosing diseases at an early stage.

Serum or plasma microRNA as biomarkers for non-small cell lung cancer

Provided are a new precursor miRNA and the applications in tumor therapy thereof. The precursor miRNA, from 5'- to 3&#x2032;-end thereof, has the structure represented by formula (I). B1 is an anti-miRNA and/or siRNA to be expressed; B2 is a sequence substantially or completely complementary to B1, and B2 is not complementary to C; C is a sequence with stem-loop structure; A1 and A2 are independently hydrogen or optionally a RNA sequence consisting of 4 to 5 bases. The precursor miRNA can be processed to form an anti-miRNA and/or siRNA in hosts. 

Precursor miRNA and applications in tumor therapy thereof

Provided is a use of miRNA-214 inhibitor in inhibiting regulatory T cells (Treg cells). The microRNA-214 (miRNA-214) can promote Treg cells, and can assist tumors in immune escape. The experiments demonstrates that the inhibition of miRNA-214 can inhibit the growth of Treg cells, thus inhibiting the growth of tumors. Therefore, miRNA-214 can be used for developing an anti-tumour drug or a drug inhibiting immune response hyperactivity.

Use of miRNA-214 inhibitor in inhibiting regulatory cells

The present invention relates to a microparticle comprising a functional microRNA/siRNA and application thereof. Specifically, disclosed is a use of a functional microRNA and/or siRNA, which is used to prepare a composition applied to a mammal. After the composition is applied, the microparticle is formed in a first part in an animal, and transported to a second part, which thereby improves physiological status of the second part or heals a disease of the second part. The second part is different from the first part. The use is beneficial for optimizing a dosing manner of the functional microRNA and/or siRNA.

Method for expressing, secreting and transferring functional microRNAs/siRNAs and application thereof

Provided is an siRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia, and particularly, provided are a method of a tandem expression for siRNA of BTK, and an siRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia.

SiRNA in tandem expression and uses thereof in treating chronic lymphocytic leukemia

The present invention relates to an avian influenza virus miRNA and the identification, detection and application thereof. In particular, a kind of specific microRNA, miR-HA-3p, is screened for the first time through detecting the microRNA expression levels in samples of animals with avian influenza. The experiments prove that the miR-HA-3p, as a microRNA marker, can be very effective in detecting avian influenza virus and avian influenza. Furthermore, inhibiting the function of miR-HA-3p can be very effective in relieving symptoms of avian influenza and treating avian influenza. The microRNA revealed in the present invention for the first time can be developed into a detection agent and a therapeutic agent as well as the corresponding kits for the detection and treatment of avian influenza (e.g., H5N1).

Avian influenza virus miRNA, and appraisal, detection, and application thereof

The invention relates to plants as functional microRNA and/or functional siRNA vehicles, the preparation methods and uses thereof. In particular, disclosed in the present invention are plants or edible portions or extracts thereof as functional microRNA and/or functional siRNA vehicles and uses thereof. Also disclosed is a method for carrying the functional microRNA and/or functional siRNA, comprising the step of orally administering the plants or edible portions or extracts thereof to a subject in need thereof, wherein the plants or edible portions thereof express and carry the functional microRNA and/or functional siRNA vehicles, and the extracts contain the functional microRNA and/or functional siRNA.

Plants as functional microRNA and/or functional siRNA carriers, preparation methods and uses thereof

Growing community of inventors

Beijing, China

Chenyu Zhang