Gradipore Limited

The Australian National University

Life Therapeutics Limited

Chenicheri Hariharan Nair

Brendon Conlan

Elizabeth Jean Seabrook

Thomas Norman Turton

Tracey Ann Edgell

May Lazar

Andrew Mark Gilbert

Lucy Jane Ryan

Philip John Roeth

Brendon Francis Conlan

Timothy John Senden

Rodney James Browitt

William Martin Burch

Dennis Rylatt

Kailing Wang

Theresa Marie Thomas

Jason Ian Kien Huat Lee

Ellie Faramus

Grace Sze Man Chan

Elena A Shats

Ellie Louise Faramus

Steven Anthony Botto

Elena Alexandra Shats

A method of removing a biological contaminant from a mixture containing a biomolecule and the biological contaminant, the method comprising: (a) placing the biomolecule and contaminant mixture in a first solvent stream, the first solvent stream being separated from a second solvent stream by an electrophoretic membrane; (b) selecting a buffer for the first solvent stream having a required pH; (c) applying an electric potential between the two solvent streams causing movement of the biomolecule through the membrane into the second solvent stream while the biological contaminant is substantially retained in the first sample stream, or if entering the membrane, being substantially prevented from entering the second solvent stream; (d) optionally, periodically stopping and reversing the electric potential to cause movement of any biological contaminants having entered the membrane to move back into the first solvent stream, wherein substantially not causing any biomolecules that have entered the second solvent stream to re-enter first solvent stream; and (e) maintaining step (c), and optional step (d) if used, until the second solvent stream contains the desired purity of biomolecule.

Removal of biological contaminants

An electrophoresis system for removing or reducing concentration of a metabolic component from blood or plasma of a subject is provided. A method for removing or reducing concentration or amount of a metabolic component in blood or plasma of a subject is also provided. The system and method include use of a set of ion permeable barriers and the application of an electrical potential across these barriers to selectively remove metabolic components from blood or plasma.

Removal of metabolic components from blood

The claims provide for detecting prions in a sample by (a) subjecting a sample to membrane-based electrophoresis to separate and/or concentrate at least some prions present in the sample; and (b) detecting and or identifying the presence of the separated and/or concentrated prions.

Prion diagnostic test

A method for the detection of fibrin in a source, in particular the in vivo detection of a fibrin in a patient, the method comprising supplying to the source or patient an amount of a detectable reagent comprising a plurality of discrete particles, each of the particles comprising a plurality of layers of carbon and being capable of binding to fibrin; and detecting the presence of the particles in the source. The particles may also comprise a detectable marker encased in said plurality of layers of carbon, the presence of said marker being capable of detection in said source.

Method for detection of fibrin clots

A method of treating blood or plasma of a subject to remove metabolic contaminants by electrophoresis. Blood or plasma from the subject is placed in a first solvent stream, the first solvent stream being separated form a second solvent stream by an electrophoretic membrane. Applying an electric potential between the two solvent streams causes movement of metabolic contaminants from the blood or plasma through the membrane into the second solvent stream while cellular and biomolecular components of the blood or plasma are substantially retained in the first sample stream, or if entering the membrane, being substantially prevented from entering the second solvent stream. Optionally, periodically stopping and reversing the electric potential causes movement of any cellular and biomolecular components of the blood or plasma having entered the membrane to move back into the first solvent stream, wherein substantially not causing any metabolic contaminants that have entered the second solvent stream to re-enter first solvent stream. The potential is maintained until the desired amount of removal of the metabolic contaminants from the blood or plasma in the first solvent stream is achieved. The treated blood or plasma in the first solvent stream is returned to the subject.

Blood-related dialysis and treatment

A system for separating biomolecules by electrophoretic separation including a first separation barrier having a defined molecular mass cut-off disposed in the first electric field area, a first restriction barrier disposed between a first cathode zone and a first separation barrier so as to define a first interstitial volume therebetween, a second restriction barrier disposed between the first anode zone and the first separation barrier so as to define a second interstitial volume therebetween, and a pumping means to provide a sample constituent in a selected one of the first interstitial and second interstitial volumes wherein upon application of the first voltage potential, a selected separation product is removed from the sample constituent through the first separation barrier and provided to the other of the first and second interstitial volumes.

Electrophoresis separation and treatment of samples

Separation of micromolecules

A method for separating components from plasma, the method comprising (I) separating the plasma into a first and second component, the first component comprising an albumin/&agr;-1-antitrypsin pool and the second component comprising plasma containing components having a molecular mass greater than albumin; (II) treating the second component to form an immunoglobulins concentrate containing immunoglobulins substantially free from components having a molecular mass less than immunoglobulins; (III) treating the immunoglobulins concentrate to remove components having a molecular mass greater than immunoglobulins; and (IV) separating albumin and &agr;-1-antitrypsin from the albumin/&agr;-1-antitrypsin pool.

Separation of plasma components

Growing community of inventors

Castle Hill, Australia

Chenicheri Hariharan Nair