Shaanxi University of Science and Technology

Xi'an Taikomed Pharmaceutical Technology Co., Ltd.

Shaanxi Panlong Pharmaceutical Co., Ltd.

Shaanxi Panlong Pharmaceutical Group Limited by Share Ltd.

Xi'an Kangyuansheng Biomedical Technology Co., Ltd.

Xixian New District Fenghou Original Pharmaceutical Technology Co., Ltd.

Chengyuan Liang

Han Li

Xingke Ju

Bin Tian

Lei Tian

Qianqian Zhao

Dan Yang

Jingyi Li

Liang Xin

Gennian Mao

Yongbo Wang

Juan Li

Yuzhi Liu

Dezhu Zhang

Xiaolin Xie

Nan Hui

Liang Qi

Xuechuan Wang

Danni Tian

Wenbo Yao

Yonghong Tang

Minyi Jia

Guaiping Qiao

Shunjun Ding

Yanjun Li

Juan Xia

Minghui Chang

Jingwen Xu

Qiao Zeng

Kangxiong Wu

Limei Wang

Taotao Qiang

Huafeng Qi

Ruina Bian

Zhao Ma

Xuhua Zhou

Yuanyuan He

Nan Qin

Shaojun Zhang

Jie Zhang

Xiuding Yang

Yuqing Zhao

Jie Li

Chunyang Shi

Zhenfeng Shi

Songsong Ruan

Wen Wang

Peiyu Zhou

Jianguo Meng

Zhong Meng

Yuting Liu

Xinhua Liu

Ouyang Yue

Yanzi Wang

Huayin Pu

Mi Wu

Kaiqi Shi

Xuechuang Wang

Xinke Ju

Mudan Xu

Qingbo Zhao

Min Li

Catherine J Lee

Maggie Lewis

Sundian Liu

Longfang Ren

Shaomeng Pei

Wei Liu

Yu Wang

Jian Zha

Jia Wan

Ning Liu

Chunchun Kong

Mengdi Hou

Manhui Zheng

Kairui Kang

Xuefeng Chen

Xeufeng Chen

Jian Cha

Juanna Song

Yanghan Liu

Lili Wen

Yunying Song

Yuecheng Lyu

Weihui Ju

Guang Tong

Wenjing Yang

Qiangian Zhao

Cong Du

Qi Lu

Jialin Li

Boyang Li

Xing Zhu

Shujun Ding

Yunfei Zhang

Qingxin Han

Bingxing Zhang

Ji Li

Mengzhou Wang

Huijie Zhang

A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed, wherein R is a phenyl substituted with an electron withdrawing group or a phenyl substituted with an electron donating group. The pleuromutilin derivative containing a thiazolo[5,4-C]pyridine side chain in the present invention exhibits good in vitro antibacterial activity and improves the problem of poor solubility of pleuromutilin derivatives.

Pleuromutilin derivative containing a thiazolo[5,4-c]pyridine side chain, and a preparation method and application thereof

A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed. The 3H-imidazo[4,5-C]pyridine pleuromutilin onium salt derivatives exhibit good water solubility and excellent activity against resistant, in vivo and in vitro antibacterial activity, and are of great value in the development of anti-resistant bacteria drugs and have good medical application prospects.

Pleuromutilin onium salt derivative containing a 3H-imidazo[4,5-c]pyridine side chain, and a preparation method and application thereof

The present invention relates to the technical field of medicinal chemistry, and particularly to a method for preparing a 3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and use thereof. Specifically, a compound of Formula I, or a pharmaceutically acceptable salt, or an optical isomer, or an isotope-substituted form thereof is provided. The compound effectively inhibits the SARS-CoV-2 3CLactivity, and is useful in the preparation of a SARS-CoV-2 3CLinhibitor to block the replication and transcription of SARS-CoV-2 viruses in patients. The compound prepared in the present invention has high in-vitro safety, and very good prospect of application in the preparation of SARS-CoV-2 3CLinhibitors and anti-SARS-CoV-2 drugs.

3-tetrazolylmethyl-1,3,5-triazin-2,4-dione compound inhibiting coronavirus 3CL protease activity and preparation method and use thereof

A method of preparing a Polygoni Milletii Rhizome tincture includes: preparing a first mixture; extracting the first mixture with 70-90% ethanol under reflux condition to obtain a first extract solution; preparing a second mixture; extracting the second mixture with 50-70% ethanol to obtain a second extract solution; and mixing the first extract solution with the second extract solution to obtain the polygoni milletii rhizome tincture. A method of preparing a Polygoni Milletii Rhizome poultice includes: reparing a Polygoni Milletii Rhizome mixture; mixing the Polygoni Milletii Rhizome mixture and a skin penetration enhancer in water; mixing a moisturizing agent and a binder in water; adding a thickener in water; mixing methylparaben and ethylparaben in 90% ethanol; mixing all solutions to form a mixture; and applying the mixture on a non-woven fabric cloth and drying to form the Polygoni Milletii Rhizome poultice.

Polygoni Milletii Rhizome compositions and methods of preparing the same

A pleuromutilin cinnamic acid ester compound with activities against antibiotic-resistant infections having the following formula (I) R, R, R, Rand Rare independently hydrogen, halogen, nitro, cyano, methoxy, trifluoromethyl, benzyloxy, aryl or dimethylamino.

Pleuromutilin cinnamic acid ester compounds with activities against antibiotic-resistant infections

Aseed extract includes the following components by weight based on a total weight of theseed extract: 0.4944-0.7142 mg/g of echinacoside, 6.624-7.617 mg/g of oleuropein, 0.4276-0.6309 mg/g of verbascoside, 3.927-4.684 mg/g of syringin, and 4.505-5.250 mg/g of forsythiaside B. A method of preparing theseed extract is disclosed. A composition for treating antibiotic-resistant infections that includes theseed extract is also disclosed.

seed extract composition and its application in antibiotic-resistant infections

A method of preparing a hydroxytyrosol sturgeon skin gelatin film with antioxidant activity anddetection ability includes: (1) mixing a neutral red indicator solution and distilled water at room temperature to obtain a mixture solution, and adding 1 mol/L NaHCOsolution to the mixture solution until discoloration to obtain an alkaline solution; (2) adding an amount of the alkaline solution obtained in step (1) to a mixture of Sturgeon skin gelatin and distilled water to obtain an alkaline gelatin solution; (3) adding hydroxytyrosol and glycerin and propylene glycol to the alkaline gelatin solution to obtain a hydroxytyrosol gelatin solution, and heating the hydroxytyrosol gelatin solution at 40-70&#xb0; C.; (4) ultrasonicating the hydroxytyrosol gelatin solution from step (3), placing the hydroxytyrol gelatin solution evenly on a clean plexiglass plate, drying the hydroxytyrol gelatin solution on an ultra-clean worktable to obtain the hydroxytyrosol sturgeon skin gelatin film.

Hydroxytyrosol sturgeon skin gelatin film with antioxidant activity anddetection ability and a method of preparing the same

Disclosed is a compound of formula I, a pharmaceutically acceptable salt, or a tautomer thereof. formula I. R, R, Rand Rare independently selected from the group consisting of hydrogen, methyl group, tert-butyl group, methoxy group, difluoromethyl, trifluoromethyl, trifluoromethoxy, nitro, halogen, phenyl and aromatic heterocyclic; Ris a hydrogen or halogen; and Ris hydrogen, C1-4 alkane or C1-4 cycloalkane.

3-triazolyl methyl-1,3,5-triazine-2,4-dione compounds and preparation method and application thereof

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. A method of preparing the compound of formula (I) is also disclosed.

Pleuromulin lipoic acid ester with antibacterial activity and a method of preparing the same

A compound with anti-drug resistant bacteria activity having the following formula (I): is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromulin 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ester with antibacterial activity and a method of preparing the same

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. The Linker is or and n is 1-6.

Protacs targeting coronavirus 3CL protease and preparation method and application thereof

Pleuromutilin (phenylthio)acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same

A compound of formula I or formula II, a pharmaceutically acceptable salt, or a tautomer thereof is disclosed. In formula I and II, n is 1-6.

Protacs based on VHL ligand targeting coronavirus 3CL protease and preparation method and application thereof

Pleuromutilin (E)-4-(1-imidazoylmethyl)cinnamic acid ester with anti-drug resistant bacteria activity and a method of preparing the same

A compound with anti-drug resistant bacteria activity having the formula (I): (I) is disclosed. The methods of preparing the compound of formula (I) are also disclosed.

Pleuromutilin 2-[(diphenylmethyl)thio] acetic acid ester with anti-drug resistant bacteria activity and a method of preparing the same

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Xi'an, China

Chengyuan Liang