Guangzhou Baiyunshan Pharmaceutical Co., Ltd.

Chenglong Yi

Xuebin Liu

Shaoxuan Zhu

Xiaona Zhang

Shuwen Xu

Chun Luo

Mao Chen

Lizhen Zheng

Fang Ye

Disclosed herein are a cephalosporin compound of formula I,   the preparation and uses thereof. A method of preparing the cephalosporin compound as disclosed herein comprises reacting a starting cephalosporin comprising a C7 amino group and a C3 thio-methyl moiety substituted with an N-containing heterocyclic group with bromoacetyl bromide and then with a N,N'-bissubstituted thiourea. Methods of treating an infectious disease are also disclosed, comprising administering to a patient in need thereof the pharmaceutical composition disclosed herein.

Cephalosporin compounds comprising a C3 thio-methyl moiety substituted with N-containing heterocyclic group, and a C7 thiourea acetamido group, their preparations and uses thereof

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Guangdong, China

Chenglong Yi