Altria Client Services LLC

Philip Morris USA Inc.

University of Virginia Patent Foundation

Micreos B.v.

Philip Morris Products S.a.

Chengalrayan Kudithipudi

Dongmei Xu

Yanxin Shen

Jesse Frederick

James A Strickland

Alec J Hayes

Jaemo Yang

Marcos Fernando De Godoy Lusso

Ujwala Warek

Robert Frank Hart, Iii

Rutger S Van Der Hoeven

Ndjido Kane

Raja Payyavula

Rutger Van Der Hoeven

Michael Paul Timko

Rajanikanth Govindarajulu

Roel Rabara

Dong Qi

Jerry Whit Morris

Elisabeth Miller

Steven Hagens

Fritz Eichenseher

Nazmul Bhuiyan

This disclosure provides tobacco plants having a mutation in PR50 and transgenic tobacco plants containing a PR50 RNAi, and methods of making and using such plants.

Tobacco having altered leaf properties and methods of making and using

The present disclosure relates to compositions and methods related to tissue-specific promoters and their uses in plants, including tobacco and cannabis. The provided trichome-specific promoters enable the expression of heterologous polynucleotides in trichome tissues.

Tissue-specific promoters in plants

The present disclosure relates to compositions and methods related to modification of trichome density and transport of metabolite and their uses in plants, including tobacco and. The provided transcription factors enable the increase in trichome density in plants.

Increasing trichome density and improving transport of metabolites in plant trichomes

Provided herein are genetic markers and a coding sequence associated with a low- or ultra-low anatabine trait in tobacco.

Genetic locus imparting a low anatabine trait in tobacco and methods of using

The present disclosure provides the identification of genes involved in sucker growth in tobacco. Also provided are promoters that are preferentially active in tobacco axillary buds. Also provided are modified tobacco plants comprising reduced or no sucker growth. Also provided are methods and compositions for producing modified tobacco plants comprising reduced or no sucker growth.

Compositions and methods for producing tobacco plants and products having reduced or eliminated suckers

The present disclosure provides metabolic signatures and genetic markers for tracking enhanced nitrogen utilization efficiency phenotypes in tobacco plants and for introgressing enhanced nitrogen utilization efficiency phenotypes into tobacco plants. The disclosure also provides tobacco plants comprising enhanced nitrogen utilization efficiency and methods to the creation of tobacco plants comprising enhanced nitrogen utilization efficiency. The disclosure also provides recombinant polynucleotides and polypeptides for enhancing nitrogen utilization efficiency in modified tobacco plants and tobacco plants comprising the provided recombinant polynucleotides and polypeptides.

Methods and compositions related to improved nitrogen utilization efficiency in tobacco

The present disclosure provides composition and methods for improving leaf quality of low-alkaloid tobacco plants. Also provided are the identification and genetic engineering of target genes (Leaf Quality Genes) for producing tobacco plants with altered total alkaloid and nicotine levels and commercially acceptable leaf grade, their development via breeding or transgenic approaches, and production of tobacco products from these tobacco plants.

Compositions and methods for producing tobacco plants and products having altered alkaloid levels with desirable leaf quality via manipulating leaf quality genes

This disclosure provides a number of sequences involved in axillary bud growth in tobacco, methods of using such sequences, tobacco plants carrying modifications to such sequences or transgenes of such sequences, and tobacco products made from tobacco leaf harvested from such plants.

Genetic control of axillary bud growth in tobacco plants

This disclosure provides a number of sequences involved in nitrogen utilization, methods of using such sequences, tobacco plants carrying modifications to such sequences, tobacco plants transgenic for such sequences, and tobacco products made from such plants.

Tobacco plants having increased nitrogen efficiency and methods of using such plants

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

Composition and methods for producing tobacco plants and products having reduced tobacco-specific nitrosamines (TSNAs)

The present disclosure provides approaches for reducing nicotine. Also provided are tobacco plants with decreased tobacco-specific nitrosamines (TSNAs). The present disclosure further provides modified tobacco plants with low nicotine and increased antioxidant capacity. Further provided are tobacco plants or material with low nicotine and low TSNAs. Also provided is cured tobacco material of the tobacco plants provided herein and tobacco products comprising this cured tobacco material.

Tobacco plants comprising reduced nicotine and reduced tobacco specific nitrosamines

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), increase phenylalanine, or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.

Growing community of inventors

Midlothian, VA, United States of America

Chengalrayan Kudithipudi