Life Technologies Corporation

Sunplus Mmobile Inc.

Cheng-Zong Bai

Dumitru Brinza

Po-Ying Chen

Hsueh-Jyh Li

Jeoffrey Schageman

Rajesh Gottimukkala

Varun Bagai

A method for compressing nucleic acid sequence data wherein each sequence read is associated with a molecular tag sequence, wherein a portion of the sequence reads alignments correspond to sequence reads mapped to a targeted fusion reference sequence includes determining a consensus sequence read for each family of sequence reads based on flow space signal measurements corresponding to the family of sequence reads, determining a consensus sequence alignment for each family of sequence reads, wherein a portion of the consensus sequence alignments correspond to the consensus sequence reads aligned with the targeted fusion reference sequence, generating a compressed data structure comprising consensus compressed data, the consensus compressed data including the consensus sequence read and the consensus sequence alignment for each family, and detecting a fusion using the consensus sequence reads and the consensus sequence alignments from the compressed data structure.

Methods for detection of fusions using compressed molecular tagged nucleic acid

The invention relates to a rake receiver and a method for de-spreading thereof. A plurality of noise branches is adopted for producing a plurality of noise components in the rake receiver. Next, a noise combining unit adjusts each noise component according to a plurality of noise weights, so as to combine the noise components to obtain an interference-plus-noise estimation value. The rake receiver eliminates the noises in the main signal generated by the signal branches through using the interference-plus-noise estimation value. Therefore, the performance of a receiving terminal can be enhanced.

Rake receiver and de-spreading method thereof

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Taipei, Taiwan

Cheng-Zong Bai