Thevax Genetics Vaccine Co., Ltd.

Cheng-Yung Chang

Chia-Mao Wu

Jiun-Ming Wu

Yi-Tsui Chiu

Chia-Kuan Peng

Hsiang-Kai Lin

Kung-Lung Lee

Chia-Hao Kang

Wei-Hsiang Lin

Fu-Hsien Chiang

Yi-Chia Lin

Wei-Lun Chang

A fusion protein for use as a hepatitis B therapeutic vaccine is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen comprising a hepatitis B virus X protein deletion mutant that lacks amino acids (aa) at least from as 21 to as 50. The protein transduction domain is a fusion polypeptide comprising a T cell sensitizing signal-transducing peptide, a linker, and a translocation peptide. The APC-binding domain or the CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen is located at the C-terminus of the protein transduction domain.

Hepatitis B therapeutic vaccines

Growing community of inventors

Hsinchu County, Taiwan

Cheng-Yung Chang