Macau University of Science and Technology

Cheng-Yu Chen

Zhi-Hong Jiang

Jing-Rong Wang

Guo-Yuan Zhu

A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, fromis used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.

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A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, fromis used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

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Taipa, Macao

Cheng-Yu Chen