Jc Medical, Inc.

Google Inc.

Micro, LLC

Microsoft Technology Licensing, LLC

Gilead Pharmasset LLC

Gilead Sciences, Inc.

Revenue Science, Inc.

Cheng Yong Yang

Brandon Gregory Walsh

Ji Zhang

Jinhua Zhu

John O Link

Adrian S Ray

Yonatan Zunger

Radhika Malpani

Usama M Fayyad

Hongmei Mo

William E Delaney, Iv

David W Oldach

William John Watkins

Paul S Bradley

Brandon G Walsh

Peter Tan

Dennis Michael McMahon

Dennis Mcmahon

Adam Leeper

John Ullman

Matthias Grundmann

Keir Banks Mierle

Jianing Wei

Tomasz Lukasz Religa

Max Wang

Zhang Li

Huitian Jiao

Weidong Zhong

Bryan Woods

Siqing Chen

Neal Rothleder

Christine Lauren Mayer

Keith Schaefer

Sundeep Vaddadi

Weixin Cai

Christie Chan

Konstantine Tsotsos

Leon Wong

Dennis Michael Mcmahon

A heart valve prosthesis can have a valve anchor with at least one U-shaped member extending about a longitudinal axis of the valve anchor. The U-shaped member can have a peak portion and a base portion. The peak portion can have an engagement structure that allows a surgeon to engage the valve anchor with a delivery device and manipulate a position of the valve anchor in situ in order to achieve optimal placement of the prosthesis at a target site within a patient.

Heart valve prosthesis

A replacement heart valve prosthesis can be delivered to or within an existing prosthesis through a valve-in-valve delivery procedure. The existing prosthesis can be a prosthetic heart valve or other device that is implanted at a target site, such as an aortic or mitral valve of the heart. The methods provided herein can allow a surgeon to position a replacement prosthesis within or adjacent to an existing prosthesis and permit the replacement prosthesis to expand into engagement against the existing prosthesis. Thereafter, the surgeon can adjust components of the replacement prosthesis, including the position of separate anchor and frame components in order to ensure accurate and secure placement of the replacement prosthesis at the target site.

Valve-in-valve delivery of a heart valve prosthesis

Methods of assembling and delivering a valve prosthesis and delivery system are disclosed herein. A method can include housing a valve prosthesis in a compacted state within a sheath of a delivery system. The valve prosthesis can include a valve anchor and a support frame coupled to the valve anchor, and the valve anchor can include a plurality of anchoring legs having a plurality of connection apertures. The method can further include slidably coupling a pin assembly around a core member so that the pin assembly is slidable longitudinally along the core member, and inserting a plurality of pins of the pin assembly through the plurality of connection apertures of the valve anchor and a plurality of lock apertures of the delivery system to engage the plurality of anchoring legs of the valve anchor.

Methods and devices for delivery of a prosthetic valve

The present disclosure relates to methods of treating a patient that has a low coronary ostia height. The methods can involve advancing a heart valve prosthesis to a native valve structure having an ostium and positioning the prosthesis to align a gap between major peaks of the prosthesis with the ostium to avoid obstruction of the ostium. The presently disclosed methods and prostheses can be effective at treating patients with a coronary ostia height of as low as 10 mm, 8 mm, 6 mm, or less.

Heart valve prosthesis placement for low coronary ostia height

A method and system for providing tone detection for a content may include receiving a request to detect a tone for a content, retrieving user data and data about the content, detecting a content environment for the content based on at least one of the user data and the data about the content, detecting the tone for the content based on the content and the content environment, inputting the content and the detected tone into a machine-learning (ML) model for modifying the tone from the detected tone to a modified tone, obtaining at least one rephrased content segment as an output from the ML model, the rephrased content segment modifying the tone of the content from the detected tone to the modified tone, and providing at least one of the detected tone or the at least one rephrased content segment for display.

Automatic tone detection and suggestion

A valve prosthesis can be manufactured by aligning a membrane along a support frame and attaching the membrane to the support frame. The membrane can have a plurality of first fibers arranged in a warp direction and a plurality of second fibers arranged in a weft direction that is transverse relative to the warp direction. The plurality of first fibers and the plurality of second fibers can be woven together. The warp and weft directions can be oriented oblique relative to a longitudinal axis of the support frame.

A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a support frame, a valve anchor comprising an anchoring leg and a plurality of U-shaped members, and a connection member coupled to the support frame and slidably coupled to the anchoring leg.

A heart valve prosthesis delivery device can be modified in situ to facilitate retrieval of the device from a patient after delivery of a heart valve prosthesis. The device can include a nose cone that permits enclosures of the device to be drawn together in an aligned configuration, reducing the likelihood that the device will get caught on the prosthesis or vasculature as the device is retrieved from the patient.

Heart valve prosthesis delivery system

In a general aspect, a method can include receiving data defining an augmented reality (AR) environment including a representation of a physical environment, and changing tracking of an AR object within the AR environment between region-tracking mode and plane-tracking mode.

Hybrid placement of objects in an augmented reality environment

Prosthetic heart valve

Systems and methods are described for providing co-presence in an augmented reality environment. The method may include controlling a first and second computing device to detect at least one plane associated with a scene of the augmented reality environment generated for a physical space, receiving, from the first computing device, a first selection of a first location within the scene and a first selection of a second location within the scene, generating a first reference marker corresponding to the first location and generating a second reference marker corresponding to the second location, receiving, from a second computing device, a second selection of the first location within the scene and a second selection of the second location within the scene, generating a reference frame and providing the reference frame to the first computing device and to the second computing device to establish co-presence in the augmented reality environment.

Providing multiplayer augmented reality experiences

A valve prosthesis and a system for delivering a valve prosthesis are described herein. The valve prosthesis can include a valve anchor having a longitudinal axis and proximal and distal end portions. The valve anchor can include a plurality of U-shaped members and a plurality of anchoring legs, each of the plurality of anchoring legs comprising a connection aperture at a distal end portion thereof and a longitudinal slot extending along a length of the anchoring leg, wherein the plurality of anchoring legs and the plurality of U-shaped members can radially expand in stages to permit a native valve structure to be interposed therebetween for anchoring the valve prosthesis relative to the native valve structure.

The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

An anchoring element for a heart valve prosthesis can include an upper support, a lower support, and a flexible connector. The upper support is configured to be positioned adjacent to a native valve structure of a patient. The upper support can include an anterior portion and a posterior portion. The lower support is separate from the upper support and can be configured to engage the native valve structure from a ventricular side. The lower support can include at least two engagement members. The flexible connector includes an upper end portion coupled to the upper support and a lower end portion coupled to the lower support. The lower support and the upper support are radially expandable from a collapsed configuration to an expanded configuration for delivery within the patient to treat a valve disorder.

Mitral valve prosthesis

Growing community of inventors

Foster City, CA, United States of America

Cheng Yong Yang