Zheng Yang Biomedical Technology Co., Ltd.

Sun, Chung Chin

Su, Cheng-yao

Lin, Cheng-chih

Cheng-Yao Su

Thierry Burnouf

Chung Chin Sun

Shan Shue Wang

Cheng-Chih Lin

A method for blood plasma protein activity preservation is provided. The method comprises the steps of mixing blood plasma with two or more protectants selected from the group consisting of triglyceride, glycerol, propylene glycol, alanine, serine, glycine, alginate, and sucrose to obtain a mixture; and lyophilizing the mixture.

Method for blood plasma protein activity preservation

The invention concerns human platelet extracts rich in growth factors (PGF) for wound healing and stem cell expansion. Accordingly the subject invention relates to a virally-inactivated growth factors-containing platelet lysate depleted of PDGF and VEGF, which is preferably enriched in TGF, IGF and EGF-rich. The present invention further concerns a method for obtaining a platelet lysate comprising the steps of contacting a starting platelet concentrate with a solvent and/or a detergent, incubating the starting platelet concentrate with the solvent and/or detergent for a period of at least 5 minutes to 6 hours, at a pH maintained in a range from about 6.0 to about 9.0, and at a temperature within the range of from 2&#xb0; C. to 50&#xb0; C., optionally removing the solvent and/or the detergent by oil extraction and obtaining an aqueous protein phase, and incubating the solvent and/or detergent-treated platelet concentrate or the aqueous protein phase with charcoal.

Virally-inactivated growth factors-containing platelet lysate depleted of PDGF and VEGF and preparation method thereof

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Taipei, Taiwan

Cheng-Yao Su