Bonraybio Co., Ltd.

Bionime Gmbh

Other

Cheng-Teng Hsu

Kuang-Li Huang

Chih-Pin Chang

Yu-Chiao Chi

Chia-Wei Chang

Hsuan-Yu Huang

Chiung-Han Wang

Chun-Mu Huang

Chieh-Hsing Chen

Hsi-Wen Huang

Hsiu-Chin Lee

Jyh-Myng Zen

Hsieh-Hsun Chung

Li-Sheng Chang

Hui-Ying Lee

Chun-Wei Su

Hsueh-Hui Yang

Mei-Shin Chiou

Jun-Wei Sue

Tung-Meng Tsai

Hueih-Jing Lyuu

Hui-Ching Lu

Hung-Chan Hsiao

Disclosed herein are methods for the detection of the presence of sperm DNA fragmentation in a semen sample. The methods include embedding of sperm cells of the semen sample in a gel, denaturing DNA of the sperm cells, and lysing the nuclear proteins of the sperm cells. The present method includes an ionic surfactant sodium dodycyl sulfate (SDS) and a chaotropic agent urea in the lysis solution for releasing DNA from protamine of chromosome, which significantly reduces the time required for lysis. A kit for detecting sperm DNA fragmentation in a semen sample is also disclosed.

Methods and kits for detecting sperm dna fragmentation

Disclosed are calibration techniques that can be implemented by a device that conducts biological tests. In certain embodiments, the device for testing a biological specimen includes a receiving mechanism to receive a carrier, a camera module arranged to capture imagery of the carrier, and a processor. Some examples of the processor can detect a calibration mode trigger. In calibration mode, the processor can divide the captured imagery into segments and selectively perform one or more calibration procedures for each segment. Then, the processor records a calibration result for each segment.

Calibration in automated testing apparatus

Disclosed are verification techniques that can be implemented by a device that conducts biological tests to verify that the specimen holding area carries a valid biological specimen. In certain embodiments, the testing device includes a receiving mechanism to receive a carrier, and the carrier includes a holding area that is to carry or to be exposed to a biological specimen. The device can also include a camera module arranged to capture imagery of the carrier, and a processor. In some examples, the processor can capture the imagery of the carrier and identify a visual cue on the carrier. Then, the processor can verify, based on a manner of how the visual cue is displayed in the captured imagery, whether the holding area carries a valid biological specimen.

Specimen verification in automated testing apparatus

Methods and kits for detecting sperm DNA fragmentation

Embodiments include a device for testing biological specimen. The device can include a receiving mechanism to receive a carrier. The carrier may include a holding area. The device includes a camera to capture a plurality of images of the holding area. A processor in the device may utilize the camera module to: adaptively select, based on the plurality of images of the holding area, an analytical algorithm suitable for a motion property that is characteristic of the biological specimen being tested; and perform a set of analytic processes that corresponds to the selected analytic algorithm on the captured imagery to generate an analytic result associated with the biological specimen.

Motion determination in automated testing apparatus

A collection bottle and a method for detecting a characteristic of a sample are provided. The collection bottle includes a body and a cover. The body of the collection bottle has an accommodating space. The cover of the collection bottle is removably assembled to the body of the collection bottle, and the cover includes a channel and a testing part. The channel of the collection bottle communicates the accommodating space and the outside environment. While the cover of the collection bottle is assembled to the body, the testing part extends toward the accommodating space.

Collection bottle and method for detecting characteristic of sample

Test strip

Embodiments include a device for testing biological specimen. The device can include a receiving mechanism to receive a carrier. The carrier may include a holding area. The device may include a camera arranged to capture a plurality of images, including a first image and a second image, of the holding area. The device may include a positioning mechanism operable to adjust a relative location of the carrier to the camera. A processor in the device may utilize the camera module to: identify an edge of the first image; cause the positioning mechanism to adjust the relative location of the carrier to the camera in a manner such that, when the camera takes the second image, an edge of the second image aligns with the identified edge of the first image; and perform a set of analytic processes on a combined image from the first and second images.

Multi-view analysis in automated testing apparatus

Embodiments disclose a device for testing biological specimen. The device includes a receiving mechanism to receive a carrier. The carrier includes a holding area that carries or has been exposed to the biological specimen. The device includes a camera module arranged to capture imagery of the holding area. The camera module includes an focusing motor operable to adjust a focal point of the camera. The device also includes a processor that is configured to utilize the camera module to determine, based on operations of the focusing motor, a volumetric property of the holding area and perform a set of analytic processes on at least a portion of the captured imagery of the holding area to determine one or more properties of the biological specimen.

Analysis accuracy improvement in automated testing apparatus

A biosensor strip includes a strip body, a working electrode and a chemical reagent layer, wherein the strip body has a conductive portion and a reaction channel. The partial wall that forms the reaction channel is a partial or an entire surface layer of the conductive portion. The reaction channel has an opening that receives the sample fluid and an electrode hole. The working electrode is embedded in the electrode hole. The chemical reagent is configured in the reaction channel and generates an electrochemical reaction with the analyte. Therefore, after the sample fluid covers the reaction channel and the working electrode via the opening, the conductive portion and the working electrode on the wall of the reaction channel generate sensing currents and output the signals via the first and second signal output sides to determine an analyte concentration in the sample fluid.

Biosensor strip

Test meter

Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1. Some embodiments further include a multi-camera configuration. These embodiments include a first camera module and a second camera module arranged to capture one or more images of the first holding area and the second holding area, respectively. The processor may perform different analytic processes on the captured images of different holding areas to determine an outcome with regard to the biological specimen.

Automated testing apparatus

The present invention relates to a method for estimating a distribution of a sample flowed from a first electrode toward a second electrode of an electrochemical test strip. A working voltage is provided between the first electrode and the second electrode for obtaining a first and a second currents, where a ratio of the first current to the second current is applied to estimate the distribution of the sample on the first and the second electrodes and an effectiveness of a measurement of a target analyte of the sample.

Growing community of inventors

Taichung, Taiwan

Cheng-Teng Hsu