Nantong University

Cheng Sun

Xiaosong Gu

Xin Tang

Qianru He

Gang Chen

Fei Ding

Chunkang Tang

Yumin Yang

Hongkui Wang

Mi Shen

Haoming Li

Xiaokun Gu

Wenfeng Su

Tianmei Qian

Yanpei Gong

Youlang Zhou

Xisosong Gu

A protein-modified PLGA microsphere can be used to construct tissue-engineered nerve. The microspheres are loaded with active substances for treating peripheral nerve injury and are bound to tissue-engineered nerves. It has been shown that the prepared tissue-engineered nerve effectively promotes nerve regeneration after peripheral nerve injury.

Protein-modified PLGA microsphere and tissue-engineered nerve constructed therewith

Ag&#x2014;Fe3O4 immunomagnetic microsphere contains poly-D-lysine modified on the surface and S100&#x3b2; and/or MBP antibody linked by an amide bond. The Ag&#x2014;Fe3O4 immunomagnetic microsphere can specifically capturing peripheral nerve tissue-derived exosomes. When the microsphere is used to extract nerve tissue-derived exosomes, the extraction yield of exosomes per unit volume of nerve tissue is high, and the nerve specificity is strong.

Method for extracting nerve tissue-derived exosomes

A differential tissue-engineered nerve including motor-like nerves and sensory-like nerves. The motor-like nerve and the sensory-like nerve respectively includes a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube as well as a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube. Schwann cells and/or fibroblasts derived from motor nerves and sensory nerves are respectively contained in surfaces or pores of the motor-like and sensory-like nerve outer tubes. Transsynaptic signal molecules Neuroligin-1 and Neuroligin-2 are contained in surfaces or pores of the motor-like and sensory-like nerve fibers. Neuroligin-1 is selectively used to specifically promote synaptic remodeling of motor neurons, while Neuroligin-2 is selectively used to specifically promote synaptic remodeling of sensory neurons, so that repair efficiency of motor nerve cells and sensory nerve cells is improved.

Construction and application of differentially regulated tissue-engineered nerve grafts

Growing community of inventors

Jiangsu, China

Cheng Sun